Abstract：
Human T cell leukemia virus type 1 (HTLV-1) is the first human oncogenic retrovirus to be discovered and causes two major diseases: a progressive neuro-inflammatory disease, termed HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), and an aggressive malignancy of T lymphocytes known as adult T cell leukemia (ATL). Innate and acquired immune responses play pivotal roles in controlling the status of HTLV-1-infected cells and such, the outcome of HTLV-1 infection. Natural killer cells (NKCs) are the effector cells of the innate immune system and are involved in controlling viral infections and several types of cancers. The ability of NKCs to trigger cytotoxicity to provide surveillance against viruses and cancer depends on the balance between the inhibitory and activating signals. In this review, we will discuss NKC function and the alterations in the frequency of these cells in HTLV-1 infection.
摘要：
人类T细胞白血病病毒1型（HTLV-1）是第一个被发现的人类致癌逆转录病毒，并导致两种主要疾病：进行性神经炎症性疾病，称为HTLV-1相关性脊髓病/热带痉挛性轻瘫（HAM/TSP），和T淋巴细胞的侵袭性恶性肿瘤，称为成人T细胞白血病（ATL）。先天和获得性免疫反应在控制HTLV-1感染细胞的状态中起关键作用，HTLV-1感染的结果。自然杀伤细胞（NKC）是先天免疫系统的效应细胞，参与控制病毒感染和几种类型的癌症。NKC触发细胞毒性以提供针对病毒和癌症的监视的能力取决于抑制和激活信号之间的平衡。在这次审查中,我们将讨论NKC功能和这些细胞在HTLV-1感染中的频率变化。
