PDF(Pubmed)
Abstract：
Previous studies suggest that dietary vitamin C is inversely associated with gastric cancer (GC), but most of them did not consider intake of fruit and vegetables. Thus, we aimed to evaluate this association within the Stomach cancer Pooling (StoP) Project, a consortium of epidemiological studies on GC.
Fourteen case-control studies were included in the analysis (5362 cases, 11,497 controls). We estimated odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for the association between dietary intake of vitamin C and GC, adjusted for relevant confounders and for intake of fruit and vegetables. The dose-response relationship was evaluated using mixed-effects logistic models with second-order fractional polynomials.
Individuals in the highest quartile of dietary vitamin C intake had reduced odds of GC compared with those in the lowest quartile (OR: 0.64; 95% CI: 0.58, 0.72). Additional adjustment for fruit and vegetables intake led to an OR of 0.85 (95% CI: 0.73, 0.98). A significant inverse association was observed for noncardia GC, as well as for both intestinal and diffuse types of the disease. The results of the dose-response analysis showed decreasing ORs of GC up to 150-200 mg/day of vitamin C (OR: 0.54; 95% CI: 0.41, 0.71), whereas ORs for higher intakes were close to 1.0.
The findings of our pooled study suggest that vitamin C is inversely associated with GC, with a potentially beneficial effect also for intakes above the currently recommended daily intake (90 mg for men and 75 mg for women).
Fourteen case-control studies were included in the analysis (5362 cases, 11,497 controls). We estimated odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for the association between dietary intake of vitamin C and GC, adjusted for relevant confounders and for intake of fruit and vegetables. The dose-response relationship was evaluated using mixed-effects logistic models with second-order fractional polynomials.
Individuals in the highest quartile of dietary vitamin C intake had reduced odds of GC compared with those in the lowest quartile (OR: 0.64; 95% CI: 0.58, 0.72). Additional adjustment for fruit and vegetables intake led to an OR of 0.85 (95% CI: 0.73, 0.98). A significant inverse association was observed for noncardia GC, as well as for both intestinal and diffuse types of the disease. The results of the dose-response analysis showed decreasing ORs of GC up to 150-200 mg/day of vitamin C (OR: 0.54; 95% CI: 0.41, 0.71), whereas ORs for higher intakes were close to 1.0.
The findings of our pooled study suggest that vitamin C is inversely associated with GC, with a potentially beneficial effect also for intakes above the currently recommended daily intake (90 mg for men and 75 mg for women).
摘要：
背景：先前的研究表明，膳食维生素C与胃癌（GC）呈负相关，但是他们中的大多数没有考虑水果和蔬菜的摄入量。因此，我们旨在评估胃癌汇集(StomachcancerPooling,StomachcancerPooling,STOP)项目中的这种关联,一个关于GC的流行病学研究联盟。
方法：纳入14项病例对照研究(5362例,11497个控件）。我们估计了维生素C的膳食摄入量与GC之间的关联的比值比（ORs）和相应的95％置信区间（CIs）。根据相关的混杂因素和水果和蔬菜的摄入量进行了调整。使用具有二阶分数多项式的混合效应逻辑模型评估剂量反应关系。
结果：膳食维生素C摄入量最高四分位数的个体与最低四分位数的个体相比，GC的几率降低（OR：0.64；95％CI：0.58，0.72）。对水果和蔬菜摄入量的额外调整导致OR为0.85（95％CI：0.73，0.98）。观察到非贲门GC的显着负相关，以及肠道和弥漫性疾病。剂量反应分析的结果表明，维生素C的GCOR降低至150-200mg/天（OR：0.54；95％CI：0.41，0.71），而较高摄入量的OR接近1.0。
结论：我们的联合研究结果表明，维生素C与GC呈负相关，对于超过目前推荐的每日摄入量（男性90mg，女性75mg）的摄入量也具有潜在的有益效果。
方法：纳入14项病例对照研究(5362例,11497个控件）。我们估计了维生素C的膳食摄入量与GC之间的关联的比值比（ORs）和相应的95％置信区间（CIs）。根据相关的混杂因素和水果和蔬菜的摄入量进行了调整。使用具有二阶分数多项式的混合效应逻辑模型评估剂量反应关系。
结果：膳食维生素C摄入量最高四分位数的个体与最低四分位数的个体相比，GC的几率降低（OR：0.64；95％CI：0.58，0.72）。对水果和蔬菜摄入量的额外调整导致OR为0.85（95％CI：0.73，0.98）。观察到非贲门GC的显着负相关，以及肠道和弥漫性疾病。剂量反应分析的结果表明，维生素C的GCOR降低至150-200mg/天（OR：0.54；95％CI：0.41，0.71），而较高摄入量的OR接近1.0。
结论：我们的联合研究结果表明，维生素C与GC呈负相关，对于超过目前推荐的每日摄入量（男性90mg，女性75mg）的摄入量也具有潜在的有益效果。
