Abstract：
Hedgehog (Hh) signaling plays a significant role in embryogenesis and several physiological processes, such as wound healing and organ homeostasis. In a pathological setting, it is associated with oncogenesis and is responsible for disease progression and poor clinical outcomes. Hedgehog signaling mediates downstream actions via Glioma Associated Oncogene Homolog (GLI) transcription factors. Inhibiting Hh signaling is an important oncological strategy in which inhibitors of the ligands SMO or GLI have been looked at. This review briefly narrates the Hh ligands, signal transduction, the target genes involved and comprehensively describes the numerous inhibitors that have been evaluated for use in various neoplastic settings.
摘要：
Hedgehog（Hh）信号在胚胎发生和一些生理过程中起着重要作用，如伤口愈合和器官稳态。在病态环境中，它与肿瘤发生有关,是疾病进展和不良临床结局的原因.Hedgehog信号通过胶质瘤相关癌基因同源物(GLI)转录因子介导下游作用。抑制Hh信号传导是重要的肿瘤学策略,其中已经研究了配体SMO或GLI的抑制剂。这篇综述简要叙述了Hh配体，信号转导，靶基因涉及并全面描述了已被评估用于各种肿瘤环境的众多抑制剂。
