Abstract：
OBJECTIVE: Aim: To analyze the role of cytokines in the progression of heart failure (HF) in patients with concomitant pathology of the thyroid gland.
METHODS: Materials and Methods: The systematization of literature data on the role of cytokines in the progression of HF in patients with concomitant thyroid pathology (TP) was carried out. The results of our own research were presented.
CONCLUSIONS: Conclusions: The final chapter in the history of the role of cytokines in the progression of HF has not yet been written. Further studies, including genetic ones, are necessary. The patients with HF have higher levels of TNFβ and IL-6, and a lower concentration of IL-4, compared to the control group. Patients with a fatal outcome of the disease, in contrast to those who survived for two years, have an increased level of TNFβ. In patients with concomitant TP, who had repeated hospitalization, a lower level was registered, compared to that under conditions of a more favorable course of heart failure. Concentrations of cytokines in the blood of patients with HF are associated with gene polymorphisms of the β-adrenoreceptor system: the C-allele of the Gly389A polymorphism of the β1-adrenoceptor gene leads to a decrease in the risk of increasing TNFα; IL-1α increases in the presence of the A-allele of the Ser49Gly polymorphism of this gene. In patients with HF and concomitant thyroid pathology, the risk of IL-6 growth increases in homozygous (C) patients for the Ser275 polymorphism of the β3 subunit of the G-protein.
METHODS: Materials and Methods: The systematization of literature data on the role of cytokines in the progression of HF in patients with concomitant thyroid pathology (TP) was carried out. The results of our own research were presented.
CONCLUSIONS: Conclusions: The final chapter in the history of the role of cytokines in the progression of HF has not yet been written. Further studies, including genetic ones, are necessary. The patients with HF have higher levels of TNFβ and IL-6, and a lower concentration of IL-4, compared to the control group. Patients with a fatal outcome of the disease, in contrast to those who survived for two years, have an increased level of TNFβ. In patients with concomitant TP, who had repeated hospitalization, a lower level was registered, compared to that under conditions of a more favorable course of heart failure. Concentrations of cytokines in the blood of patients with HF are associated with gene polymorphisms of the β-adrenoreceptor system: the C-allele of the Gly389A polymorphism of the β1-adrenoceptor gene leads to a decrease in the risk of increasing TNFα; IL-1α increases in the presence of the A-allele of the Ser49Gly polymorphism of this gene. In patients with HF and concomitant thyroid pathology, the risk of IL-6 growth increases in homozygous (C) patients for the Ser275 polymorphism of the β3 subunit of the G-protein.
摘要：
目的：目的：分析细胞因子在伴有甲状腺病理的心力衰竭（HF）进展中的作用。
方法：材料和方法：对伴随甲状腺病理（TP）的患者中细胞因子在HF进展中的作用的文献资料进行系统化。介绍了我们自己的研究结果。
结论：结论：关于细胞因子在HF进展中的作用的历史的最后一章尚未撰写。进一步研究,包括遗传基因，是必要的。与对照组相比，HF患者的TNFβ和IL-6水平较高，IL-4浓度较低。患有致命疾病的患者，与那些活了两年的人相比，具有增加的TNFβ水平。在合并TP的患者中，反复住院的人，注册了一个较低的级别，与心力衰竭过程更有利的条件相比。HF患者血液中细胞因子的浓度与β-肾上腺素受体系统的基因多态性有关：β1-肾上腺素受体基因的Gly389A多态性的C等位基因导致TNFα增加的风险降低；IL-1α在该基因Ser49Gly多态性的A等位基因存在下增加。在患有HF和伴随甲状腺病理的患者中，纯合（C）患者中G蛋白β3亚基的Ser275多态性的IL-6生长风险增加。
方法：材料和方法：对伴随甲状腺病理（TP）的患者中细胞因子在HF进展中的作用的文献资料进行系统化。介绍了我们自己的研究结果。
结论：结论：关于细胞因子在HF进展中的作用的历史的最后一章尚未撰写。进一步研究,包括遗传基因，是必要的。与对照组相比，HF患者的TNFβ和IL-6水平较高，IL-4浓度较低。患有致命疾病的患者，与那些活了两年的人相比，具有增加的TNFβ水平。在合并TP的患者中，反复住院的人，注册了一个较低的级别，与心力衰竭过程更有利的条件相比。HF患者血液中细胞因子的浓度与β-肾上腺素受体系统的基因多态性有关：β1-肾上腺素受体基因的Gly389A多态性的C等位基因导致TNFα增加的风险降低；IL-1α在该基因Ser49Gly多态性的A等位基因存在下增加。在患有HF和伴随甲状腺病理的患者中，纯合（C）患者中G蛋白β3亚基的Ser275多态性的IL-6生长风险增加。
