Abstract：
Impulsivity is related to a host of mental and behavioral problems. It is a complex construct with many different manifestations, most of which are heritable. The genetic compositions of these impulsivity manifestations, however, remain unclear. A number of genome-wide association studies (GWAS) and post-GWAS analyses have tried to address this issue. We conducted a systematic review of all GWAS and post-GWAS analyses of impulsivity published up to December 2023. Available data suggest that single nucleotide polymorphisms (SNPs) in more than a dozen of genes (e.g., CADM2, CTNNA2, GPM6B) are associated with different measures of impulsivity at genome-wide significant levels. Post-GWAS analyses further show that different measures of impulsivity are subject to different degrees of genetic influence, share few genetic variants, and have divergent genetic overlap with basic personality traits such as extroversion and neuroticism, cognitive ability, psychiatric disorders, substance use, and obesity. These findings shed light on controversies in the conceptualization and measurement of impulsivity, while providing new insights on the underlying mechanisms that yoke impulsivity to psychopathology.
摘要：
冲动性与一系列精神和行为问题有关。这是一个复杂的结构，有许多不同的表现，其中大部分是可遗传的。这些冲动表现的遗传组成，然而,仍然不清楚。许多全基因组关联研究（GWAS）和GWAS后分析都试图解决这个问题。我们对截至2023年12月发表的所有GWAS和GWAS后冲动性分析进行了系统评价。现有数据表明，在十几个基因中的单核苷酸多态性(SNPs)(例如，CADM2，CTNNA2，GPM6B）与全基因组显着水平的冲动性不同度量相关。后GWAS分析进一步表明，不同的冲动措施受到不同程度的遗传影响，几乎没有遗传变异，并且与外向性和神经质等基本人格特质有不同的遗传重叠，认知能力,精神疾病,物质使用,和肥胖。这些发现揭示了冲动性概念化和测量方面的争议，同时提供新的见解，使冲动与精神病理学有关的潜在机制。
