Abstract：
Anti-inflammatory activities of catechin-rich green tea extract (GTE) in obese rodents protect against metabolic endotoxemia by decreasing intestinal permeability and absorption of gut-derived endotoxin. However, translation to human health has not been established. We hypothesized that GTE would reduce endotoxemia by decreasing gut permeability and intestinal and systemic inflammation in persons with metabolic syndrome (MetS) compared with healthy persons. A randomized, double-blind, placebo-controlled, crossover trial in healthy adults (n = 19, 34 ± 2 years) and adults with MetS (n = 21, 40 ± 3 years) examined 4-week administration of a decaffeinated GTE confection (890 mg/d total catechins) on serum endotoxin, intestinal permeability, gut and systemic inflammation, and cardiometabolic parameters. Compared with the placebo, the GTE confection decreased serum endotoxin (P = .023) in both healthy persons and those with MetS, while increasing concentrations of circulating catechins (P < .0001) and γ-valerolactones (P = .0001). Fecal calprotectin (P = .029) and myeloperoxidase (P = .048) concentrations were decreased by GTE regardless of health status. Following the ingestion of gut permeability probes, urinary lactose/mannitol (P = .043) but not sucralose/erythritol (P > .05) was decreased by GTE regardless of health status. No between-treatment differences (P > .05) were observed for plasma aminotransferases, blood pressure, plasma lipids, or body mass nor were plasma tumor necrosis factor-α, interleukin-6, or the ratio of lipopolysaccharide-binding protein/soluble cluster of differentiation-14 affected. However, fasting glucose in both study groups was decreased (P = .029) by the GTE confection compared with within-treatment arm baseline concentrations. These findings demonstrate that catechin-rich GTE is effective to decrease circulating endotoxin and improve glycemic control in healthy adults and those with MetS, likely by reducing gut inflammation and small intestinal permeability but without affecting systemic inflammation.
摘要：
富含儿茶素的绿茶提取物（GTE）在肥胖啮齿动物中的抗炎活性通过降低肠道通透性和肠源性内毒素的吸收来预防代谢性内毒素血症。然而,人类健康的翻译尚未建立。我们假设与健康人相比，GTE可以通过降低代谢综合征（MetS）患者的肠道通透性以及肠道和全身性炎症来减少内毒素血症。一个随机的，双盲,安慰剂对照,在健康成年人（n=19，34±2岁）和患有MetS的成年人（n=21，40±3岁）中的交叉试验检查了对血清内毒素的脱咖啡因GTE甜食（890mg/d总儿茶素）的4周给药，肠通透性,肠道和全身炎症，和心脏代谢参数。与安慰剂相比，GTE甜食降低了健康人和MetS患者的血清内毒素（P=0.023），同时增加循环儿茶素（P<0.0001）和γ-戊内酯（P=0.0001）的浓度。无论健康状况如何，GTE均降低了粪便钙卫蛋白（P=.029）和髓过氧化物酶（P=.048）的浓度。摄入肠道通透性探针后，尿乳糖/甘露醇（P=.043），但三氯半乳蔗糖/赤藓糖醇（P>.05）不考虑健康状况。血浆转氨酶无治疗间差异（P>0.05），血压,血浆脂质，或体重，血浆肿瘤坏死因子-α，白细胞介素6或脂多糖结合蛋白/可溶性分化簇14的比例受到影响。然而,与治疗内组基线浓度相比,GTE甜食降低了两个研究组的空腹血糖(P=0.029).这些发现表明，富含儿茶素的GTE可有效减少健康成人和MetS患者的循环内毒素并改善血糖控制。可能通过减少肠道炎症和小肠通透性，但不影响全身炎症。
