PDF(Pubmed)
Abstract：
OBJECTIVE: A systematic review of published data was carried out to assess the caries-preventive effects of xylitol chewing gums and candies in children.
METHODS: Electronic and hand searches were performed to find clinical studies on the effects of xylitol chewing gums and candies on dental caries in children (≤ 18 years). Prospective randomised or controlled clinical trials published before 2023 were included in the review.
RESULTS: The initial search identified 365 titles to be evaluated. After applying inclusion and exclusion criteria, 15 articles with either fair or low quality were reviewed. Nine articles studied chewing gums, five candies, and one both of them. In the ten evaluated xylitol chewing gum studies xylitol consumption significantly reduced caries occurrence when compared with no treatment or a placebo polyol gum. The effect was clinically significant in studies with high or moderate caries level at study baseline. The results also suggested that the caries-reducing effect of xylitol gums may differ from sorbitol/polyol gums. In five of the six heterogenous xylitol candy studies, no caries-reducing effect was found independent of caries level. In addition to caries level, also the daily xylitol dose was a confounding factor.
CONCLUSIONS: The present findings suggest that the caries-reducing effect of adding xylitol chewing gum to the daily diet has been well demonstrated in children and adolescents with high or moderate caries level at study baseline. Xylitol gum use could benefit subjects with active incipient caries lesions on smooth tooth surfaces.
METHODS: Electronic and hand searches were performed to find clinical studies on the effects of xylitol chewing gums and candies on dental caries in children (≤ 18 years). Prospective randomised or controlled clinical trials published before 2023 were included in the review.
RESULTS: The initial search identified 365 titles to be evaluated. After applying inclusion and exclusion criteria, 15 articles with either fair or low quality were reviewed. Nine articles studied chewing gums, five candies, and one both of them. In the ten evaluated xylitol chewing gum studies xylitol consumption significantly reduced caries occurrence when compared with no treatment or a placebo polyol gum. The effect was clinically significant in studies with high or moderate caries level at study baseline. The results also suggested that the caries-reducing effect of xylitol gums may differ from sorbitol/polyol gums. In five of the six heterogenous xylitol candy studies, no caries-reducing effect was found independent of caries level. In addition to caries level, also the daily xylitol dose was a confounding factor.
CONCLUSIONS: The present findings suggest that the caries-reducing effect of adding xylitol chewing gum to the daily diet has been well demonstrated in children and adolescents with high or moderate caries level at study baseline. Xylitol gum use could benefit subjects with active incipient caries lesions on smooth tooth surfaces.
摘要：
目的：对已发表的数据进行系统评价，以评估木糖醇口香糖和糖果对儿童龋齿的预防作用。
方法：进行电子和手搜索，以寻找木糖醇口香糖和糖果对儿童（≤18岁）龋齿影响的临床研究。2023年之前发表的前瞻性随机或对照临床试验被纳入审查。
结果：最初的搜索确定了要评估的365个标题。在应用纳入和排除标准后，共审查了15篇质量一般或低质量的文章。九篇文章研究了口香糖，五个糖果,和他们两个中的一个。在十项评估的木糖醇口香糖研究中，与没有治疗或安慰剂多元醇口香糖相比，木糖醇的消耗显着减少了龋齿的发生。在研究基线时具有高或中度龋齿水平的研究中,该效果在临床上是显著的。结果还表明木糖醇树胶的龋齿减少效果可能不同于山梨糖醇/多元醇树胶。在六个异质木糖醇糖果研究中的五个，没有发现与龋齿水平无关的龋齿减少作用。除了龋齿水平，每日木糖醇剂量也是一个混杂因素。
结论：目前的研究结果表明，在日常饮食中添加木糖醇口香糖的防龋作用已在研究基线时具有高或中度龋齿水平的儿童和青少年中得到了很好的证明。使用木糖醇胶可以使在光滑牙齿表面上有活跃的早期龋齿病变的受试者受益。
方法：进行电子和手搜索，以寻找木糖醇口香糖和糖果对儿童（≤18岁）龋齿影响的临床研究。2023年之前发表的前瞻性随机或对照临床试验被纳入审查。
结果：最初的搜索确定了要评估的365个标题。在应用纳入和排除标准后，共审查了15篇质量一般或低质量的文章。九篇文章研究了口香糖，五个糖果,和他们两个中的一个。在十项评估的木糖醇口香糖研究中，与没有治疗或安慰剂多元醇口香糖相比，木糖醇的消耗显着减少了龋齿的发生。在研究基线时具有高或中度龋齿水平的研究中,该效果在临床上是显著的。结果还表明木糖醇树胶的龋齿减少效果可能不同于山梨糖醇/多元醇树胶。在六个异质木糖醇糖果研究中的五个，没有发现与龋齿水平无关的龋齿减少作用。除了龋齿水平，每日木糖醇剂量也是一个混杂因素。
结论：目前的研究结果表明，在日常饮食中添加木糖醇口香糖的防龋作用已在研究基线时具有高或中度龋齿水平的儿童和青少年中得到了很好的证明。使用木糖醇胶可以使在光滑牙齿表面上有活跃的早期龋齿病变的受试者受益。
