关键词: Gastrula History of developmental biology Organizer

Mesh : Animals Gastrula Microscopy / methods Organizers, Embryonic History, 20th Century Embryology / history methods

来  源:   DOI:10.1016/j.cdev.2024.203909

Abstract:
The discovery of the amphibian gastrula organizer and its publication by Hans Spemann and Hilde Mangold in 1924 is a foundation of experimental embryology, and has shaped our understanding of embryonic induction and pattern formation in vertebrates until today. The original publication is a piece of scientific art, characterized by the meticulous hand drawings by Hilde Mangold, as well as the text that develops mechanistic concepts of modern embryology. While historic microphotographs of specimens got lost, the original microscope slides and Hilde Mangold\'s laboratory notebook have been secured in embryological collections until today. Here, we make the original data of the six embryonic specimens reported in 1924, as well as the laboratory notebook, available in an accessible digital format. Together, these data shed light on the scientific process that led to the discovery, and should help to make the experiments on the most important signalling center in early vertebrate development transparent for generations of embryologists to come.
摘要:
两栖动物胃组织者的发现及其在1924年由HansSpemann和HildeMangold出版,是实验胚胎学的基础,并塑造了我们对脊椎动物胚胎诱导和模式形成的理解,直到今天。原始出版物是科学艺术,以HildeMangold细致的手绘为特征,以及发展现代胚胎学机械概念的文本。虽然标本的历史显微照片丢失了,直到今天,原始的显微镜载玻片和HildeMangold\的实验室笔记本都已保存在胚胎学收藏中。这里,我们制作了1924年报告的六个胚胎标本的原始数据,以及实验室笔记本,以可访问的数字格式提供。一起,这些数据揭示了导致这一发现的科学过程,并且应该有助于使早期脊椎动物发育中最重要的信号中心的实验对后代的胚胎学家透明。
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