重球皂苷通过结合 KEAP1 并调节 Nrf2 和 MAPK 途径减轻革兰氏阴性菌诱导的炎性痤疮.
关键词: Gram-negative bacteria Rhizoma Paridis acne vulgaris anti-inflammation kelch-like ECH-associated protein 1 mitogen-activated protein kinase polyphyllin H
Mesh : Humans Mitogen-Activated Protein Kinases / metabolism NF-E2-Related Factor 2 / genetics metabolism Kelch-Like ECH-Associated Protein 1 / genetics metabolism Lipopolysaccharides / adverse effects Saponins / pharmacology therapeutic use Molecular Docking Simulation Anti-Inflammatory Agents / therapeutic use NF-kappa B / metabolism Gram-Negative Bacteria / metabolism Acne Vulgaris / drug therapy Heme Oxygenase-1 / genetics metabolism Inflammation / metabolism
来 源:
DOI:10.1111/jcmm.18146
PDF(Pubmed)