Abstract：
UNASSIGNED: People with progressive multiple sclerosis (PMS) present motor (eg, walking) and cognitive impairments, and report fatigue. Fatigue encompasses fatigability which is objectively measured by the capacity to sustain a motor or cognitive task.
UNASSIGNED: To investigate the prevalence of walking and cognitive fatigability (CF) and the associated clinical characteristics in a large sample of PMS patients.
UNASSIGNED: PMS patients (25-65 years old) were included from 11 sites (Europe and North America), having cognitive impairment (1.28 standard deviation below normative data for the symbol digit modality test [SDMT]). Walking fatigability (WF) was assessed using the distance walk index (DWI) and CF using the SDMT (scores from the last 30 seconds compared to the first 30 seconds). Additional measures were: cognitive assessment-Brief International Cognitive Assessment for multiple sclerosis (MS), cardiorespiratory fitness, 6-minute walk, physical activity, depressive symptoms, perceived fatigue-Modified Fatigue Impact Scale (MFIS), MS impact-MSIS-29, and walking ability.
UNASSIGNED: Of 298 participants, 153 (51%) presented WF (DWI = -28.9 ± 22.1%) and 196 (66%) presented CF (-29.7 ± 15%). Clinical characteristics (EDSS, disease duration, and use of assistive device) were worse in patients with versus without WF. They also presented worse scores on MSIS-29 physical, MFIS total and physical and reduced physical capacity. CF patients scored better in the MSIS-29 physical and MFIS psychosocial, compared to non-CF group. Magnitude of CF and WF were not related.
UNASSIGNED: Half of the cognitively-impaired PMS population presented WF which was associated with higher disability, physical functions, and fatigue. There was a high prevalence of CF but without strong associations with clinical, cognitive, and physical functions.
UNASSIGNED: The \"CogEx-study,\" www.clinicaltrial.gov identifier number: NCT03679468.
UNASSIGNED: To investigate the prevalence of walking and cognitive fatigability (CF) and the associated clinical characteristics in a large sample of PMS patients.
UNASSIGNED: PMS patients (25-65 years old) were included from 11 sites (Europe and North America), having cognitive impairment (1.28 standard deviation below normative data for the symbol digit modality test [SDMT]). Walking fatigability (WF) was assessed using the distance walk index (DWI) and CF using the SDMT (scores from the last 30 seconds compared to the first 30 seconds). Additional measures were: cognitive assessment-Brief International Cognitive Assessment for multiple sclerosis (MS), cardiorespiratory fitness, 6-minute walk, physical activity, depressive symptoms, perceived fatigue-Modified Fatigue Impact Scale (MFIS), MS impact-MSIS-29, and walking ability.
UNASSIGNED: Of 298 participants, 153 (51%) presented WF (DWI = -28.9 ± 22.1%) and 196 (66%) presented CF (-29.7 ± 15%). Clinical characteristics (EDSS, disease duration, and use of assistive device) were worse in patients with versus without WF. They also presented worse scores on MSIS-29 physical, MFIS total and physical and reduced physical capacity. CF patients scored better in the MSIS-29 physical and MFIS psychosocial, compared to non-CF group. Magnitude of CF and WF were not related.
UNASSIGNED: Half of the cognitively-impaired PMS population presented WF which was associated with higher disability, physical functions, and fatigue. There was a high prevalence of CF but without strong associations with clinical, cognitive, and physical functions.
UNASSIGNED: The \"CogEx-study,\" www.clinicaltrial.gov identifier number: NCT03679468.
摘要：
■患有进行性多发性硬化症（PMS）的人表现出运动（例如，步行)和认知障碍，报告疲劳。疲劳包括通过维持运动或认知任务的能力客观地测量的易疲劳性。
■调查大样本PMS患者的步行和认知疲劳性（CF）的患病率以及相关的临床特征。
■PMS患者（25-65岁）来自11个地点（欧洲和北美），有认知障碍(符号数字模态测试[SDMT]的标准数据以下1.28标准差)。使用距离步行指数（DWI）和使用SDMT（最后30秒与前30秒相比的分数）评估步行疲劳性（WF）。其他措施是：认知评估-多发性硬化症（MS）的简短国际认知评估，心肺健康，步行6分钟,身体活动,抑郁症状,感知疲劳-修正疲劳影响量表(MFIS)，MSImpact-MSIS-29和行走能力。
■在298名参与者中，153（51％）呈现WF（DWI=-28.9±22.1％），196（66％）呈现CF（-29.7±15％）。临床特征（EDSS，疾病持续时间,与没有WF的患者相比，使用辅助设备）的情况更差。他们在MSIS-29的身体素质上也表现得更差，MFIS总和物理和减少的物理能力。CF患者在MSIS-29身体和MFIS社会心理方面得分较高，与非CF组相比。CF和WF的大小无关。
■一半的认知受损PMS人群表现出与更高残疾相关的WF，物理功能，和疲劳。CF的患病率很高，但与临床无关，认知，和物理功能。
■CogEx研究，\"www.clinicaltrial.gov标识号：NCT03679468。
■调查大样本PMS患者的步行和认知疲劳性（CF）的患病率以及相关的临床特征。
■PMS患者（25-65岁）来自11个地点（欧洲和北美），有认知障碍(符号数字模态测试[SDMT]的标准数据以下1.28标准差)。使用距离步行指数（DWI）和使用SDMT（最后30秒与前30秒相比的分数）评估步行疲劳性（WF）。其他措施是：认知评估-多发性硬化症（MS）的简短国际认知评估，心肺健康，步行6分钟,身体活动,抑郁症状,感知疲劳-修正疲劳影响量表(MFIS)，MSImpact-MSIS-29和行走能力。
■在298名参与者中，153（51％）呈现WF（DWI=-28.9±22.1％），196（66％）呈现CF（-29.7±15％）。临床特征（EDSS，疾病持续时间,与没有WF的患者相比，使用辅助设备）的情况更差。他们在MSIS-29的身体素质上也表现得更差，MFIS总和物理和减少的物理能力。CF患者在MSIS-29身体和MFIS社会心理方面得分较高，与非CF组相比。CF和WF的大小无关。
■一半的认知受损PMS人群表现出与更高残疾相关的WF，物理功能，和疲劳。CF的患病率很高，但与临床无关，认知，和物理功能。
■CogEx研究，\"www.clinicaltrial.gov标识号：NCT03679468。
