PDF(Pubmed)
Abstract：
Bladder cancer is a highly prevalent malignancy that presents significant difficulties in the management of wounds following surgery. The present study investigated the critical necessity to optimize wound healing techniques in patients undergoing bladder cancer surgery by contrasting conventional approaches with advanced modalities in order to promote recovery and mitigate complications. The study assessed the efficacy of conventional and advanced wound healing methods in these patients, taking into account the complex interaction of patient-specific factors and surgical complexities. A cross-sectional analysis was performed on 120 patients who underwent bladder cancer surgery at the first affiliated hospital of Wenzhou Medical University. In addition to medical record evaluations and direct wound assessments, patient interviews were utilized to gather information regarding demographics, surgical specifics, wound healing methodologies and postoperative results. Survival analysis and logistic regression were utilized in statistical analysis, with potential confounding variables such as age, comorbidities and type of surgery being accounted for. Advanced wound healing techniques, such as negative pressure wound therapy, tissue-engineered products, bioactive dressings and platelet-rich plasma (PRP), exhibited distinct advantage in comparison with conventional suturing. The aforementioned techniques, especially PRP, resulted in expedited wound healing, decreased rates of complications (p < 0.05) and enhanced secondary outcomes, including curtailed hospital stays and decreased rates of readmissions. PRP therapy, in particular, demonstrated significant improvements with the faster mean time to wound healing of 9 ± 2 days and lower complication incidence of 2 (6.7%) (p < 0.05), indicating its superior efficacy. A subgroup analysis revealed that younger patients, males and those undergoing laparoscopic surgery exhibited superior outcomes (p < 0.05). The results were further supported by logistic regression and Cox proportional hazards models, which further indicated that sophisticated techniques, notably PRP therapy with a hazard ratio of 3.00 (2.00-4.50) and adjusted odds ratio of 0.20 (0.09-0.43), were effective in improving postoperative recovery. The research clarified the significant advantages that advanced wound healing techniques offered in postoperative care of patients diagnosed with bladder cancer. By customizing these methods to suit the unique requirements of individual patients and specific circumstances of surgical procedures, they can significantly enhance the recuperation process after surgery and set a new standard for patient care.
摘要：
膀胱癌是一种非常普遍的恶性肿瘤，在手术后的伤口处理中存在很大的困难。本研究通过将常规方法与先进方法进行对比，以促进康复和减轻并发症，调查了优化膀胱癌手术患者伤口愈合技术的关键必要性。该研究评估了常规和高级伤口愈合方法对这些患者的疗效，考虑到患者特异性因素和手术复杂性的复杂相互作用。方法对温州医科大学附属第一医院行膀胱癌手术的120例患者进行横断面分析。除了医疗记录评估和直接伤口评估，患者访谈用于收集有关人口统计的信息，手术细节，伤口愈合方法和术后结果。生存分析和逻辑回归分析用于统计分析，与潜在的混杂变量，如年龄，合并症和手术类型。先进的伤口愈合技术，如负压伤口治疗，组织工程产品，生物活性敷料和富含血小板的血浆（PRP），与传统缝合相比，表现出明显的优势。上述技术,尤其是PRP,导致伤口加速愈合，并发症发生率降低（p<0.05），次要结局增强，包括缩短住院时间和降低再入院率。PRP治疗,特别是,显示出显着改善，平均伤口愈合时间为9±2天，并发症发生率为2（6.7％）（p<0.05），表明其优越的疗效。一项亚组分析显示，年轻患者，男性和接受腹腔镜手术的患者表现出更好的结局(p<0.05).结果得到了逻辑回归和Cox比例风险模型的进一步支持，这进一步表明，复杂的技术，特别是PRP治疗的风险比为3.00（2.00-4.50），调整后的比值比为0.20（0.09-0.43），能有效改善术后恢复。该研究阐明了先进的伤口愈合技术在诊断为膀胱癌的患者的术后护理中提供的显着优势。通过定制这些方法，以适应个别患者的独特要求和外科手术的具体情况，它们可以显着增强手术后的康复过程，并为患者护理树立新的标准。
