Abstract：
Background and Purpose Intrinsic capacity (IC) has been shown to have the greatest impact on an individual\'s health status and health trajectory and can independently predict adverse outcomes such as mortality and care dependency in older adults. However, the current understanding of adverse outcomes associated with IC is incomplete. Methods A scoping review of the literature from PubMed, Web of Science (WOS), The Cochrane Library, CINAHL, and Embase databases was conducted from January 2015 to March 2023 to identify articles related to the adverse outcomes associated with IC in older adults. Results 711 studies met screening criteria, and 25 studies met inclusion criteria. These studies reported a total of 17 adverse outcomes related to IC across four domains. (1) Adverse outcomes in the physiological function domains included frailty, pneumonia onset, memory impairment, polypharmacy, incontinence, and poor/fair self-rated health. (2) Clinical outcomes domains included IADL disability, ADL disability, mortality, falls, autonomy decline, and incident dependence. (3) The resource utilization domains included hospitalization, nursing home stays, polypharmacy healthcare costs, and emergency department visits. (4) The other domains mainly included poor quality of life. Conclusion It is evident that IC decline in older adults is associated with a broad spectrum of adverse outcomes spanning cognitive function, activity ability, sensory perception, physical and mental health and living standards. Future studies should further deepen the exploration of IC.
摘要：
背景和目的内在能力（IC）已被证明对个体的健康状况和健康轨迹具有最大的影响，并且可以独立预测老年人的死亡率和护理依赖性等不良后果。然而,目前对与IC相关的不良结局的理解是不完整的.方法对PubMed的文献进行范围审查，WebofScience(WOS),科克伦图书馆,CINAHL,和Embase数据库于2015年1月至2023年3月进行,以确定与老年人IC相关的不良结局相关的文章.结果711项研究符合筛选标准，25项研究符合纳入标准。这些研究报告了总共17个与IC相关的不良结局，涉及四个领域。(1)生理功能领域的不良结局包括虚弱，肺炎发作，记忆障碍,多药，失禁,和不良/公平的自我评价健康。(2)临床结果领域包括IADL残疾，ADL残疾，死亡率,falls,自主性下降，和事件依赖。(3)资源利用领域包括住院，疗养院住宿,多药房医疗保健成本，急诊部门的访问。(4)其他领域主要包括生活质量差。结论明显的是，老年人的IC下降与广泛的认知功能不良结局有关。活动能力,感官知觉，身心健康和生活水平。未来的研究应进一步深化集成电路的探索。
