PDF(Pubmed)
Abstract：
Most studies focus on dynamic cerebral autoregulation (dCA) in the middle cerebral artery (MCA), and few studies investigated neurovascular coupling (NVC) and dCA in the posterior cerebral artery (PCA). We investigated NVC and dCA of the PCA in healthy volunteers to identify sex differences.
Thirty men and 30 age-matched women completed dCA and NCV assessments. The cerebral blood flow velocity (CBFV) and mean arterial pressure were evaluated using transcranial Doppler ultrasound and a servo-controlled plethysmograph, respectively. The dCA parameters were analyzed using transfer function analysis. The NCV was evaluated by eyes-open and eyes-closed (24 s each) periodically based on voice prompts. The eyes-open visual stimulation comprised silent reading of Beijing-related tourist information.
The PCA gain was lower than that of the MCA in all frequency ranges (all p < 0.05). Phase was consistent across the cerebrovascular territories. The cerebrovascular conductance index (CVCi) and mean CBFV (MV) of the PCA were significantly higher during the eyes-open than eyes-closed period (CVCi: 0.50 ± 0.12 vs. 0.38 ± 0.10; MV: 42.89 ± 8.49 vs. 32.98 ± 7.25, both p < 0.001). The PCA dCA and NVC were similar between the sexes.
We assessed two major mechanisms that maintain cerebral hemodynamic stability in healthy men and women. The visual stimulation-evoked CBFV of the PCA was significantly increased compared to that during rest, confirming the activation of NVC. Men and women have similar functions in PCA dCA and NCV.
Thirty men and 30 age-matched women completed dCA and NCV assessments. The cerebral blood flow velocity (CBFV) and mean arterial pressure were evaluated using transcranial Doppler ultrasound and a servo-controlled plethysmograph, respectively. The dCA parameters were analyzed using transfer function analysis. The NCV was evaluated by eyes-open and eyes-closed (24 s each) periodically based on voice prompts. The eyes-open visual stimulation comprised silent reading of Beijing-related tourist information.
The PCA gain was lower than that of the MCA in all frequency ranges (all p < 0.05). Phase was consistent across the cerebrovascular territories. The cerebrovascular conductance index (CVCi) and mean CBFV (MV) of the PCA were significantly higher during the eyes-open than eyes-closed period (CVCi: 0.50 ± 0.12 vs. 0.38 ± 0.10; MV: 42.89 ± 8.49 vs. 32.98 ± 7.25, both p < 0.001). The PCA dCA and NVC were similar between the sexes.
We assessed two major mechanisms that maintain cerebral hemodynamic stability in healthy men and women. The visual stimulation-evoked CBFV of the PCA was significantly increased compared to that during rest, confirming the activation of NVC. Men and women have similar functions in PCA dCA and NCV.
摘要：
目的：大多数研究集中在大脑中动脉（MCA）的动态脑自动调节（dCA），很少有研究研究大脑后动脉（PCA）中的神经血管偶联（NVC）和dCA。我们调查了健康志愿者中PCA的NVC和dCA，以确定性别差异。
方法：30名男性和30名年龄匹配的女性完成了dCA和NCV评估。使用经颅多普勒超声和伺服控制的体积描记器评估脑血流速度（CBFV）和平均动脉压，分别。使用传递函数分析来分析dCA参数。基于语音提示,通过周期性地睁眼和闭眼(每个24s)来评估NCV。睁大眼睛的视觉刺激包括对北京相关旅游信息的无声阅读。
结果：在所有频率范围内，PCA增益均低于MCA（所有p<0.05）。整个脑血管区域的相位一致。睁眼期间PCA的脑血管电导指数（CVCi）和平均CBFV（MV）明显高于闭眼期间（CVCi：0.50±0.12vs.0.38±0.10；MV：42.89±8.49vs.32.98±7.25，两者p<0.001)。性别之间的PCAdCA和NVC相似。
结论：我们评估了维持健康男性和女性脑血流动力学稳定的两种主要机制。与休息时相比，PCA的视觉刺激诱发的CBFV显着增加，确认NVC的激活。男性和女性在PCAdCA和NCV中具有相似的功能。
方法：30名男性和30名年龄匹配的女性完成了dCA和NCV评估。使用经颅多普勒超声和伺服控制的体积描记器评估脑血流速度（CBFV）和平均动脉压，分别。使用传递函数分析来分析dCA参数。基于语音提示,通过周期性地睁眼和闭眼(每个24s)来评估NCV。睁大眼睛的视觉刺激包括对北京相关旅游信息的无声阅读。
结果：在所有频率范围内，PCA增益均低于MCA（所有p<0.05）。整个脑血管区域的相位一致。睁眼期间PCA的脑血管电导指数（CVCi）和平均CBFV（MV）明显高于闭眼期间（CVCi：0.50±0.12vs.0.38±0.10；MV：42.89±8.49vs.32.98±7.25，两者p<0.001)。性别之间的PCAdCA和NVC相似。
结论：我们评估了维持健康男性和女性脑血流动力学稳定的两种主要机制。与休息时相比，PCA的视觉刺激诱发的CBFV显着增加，确认NVC的激活。男性和女性在PCAdCA和NCV中具有相似的功能。
