Thirty men and 30 age-matched women completed dCA and NCV assessments. The cerebral blood flow velocity (CBFV) and mean arterial pressure were evaluated using transcranial Doppler ultrasound and a servo-controlled plethysmograph, respectively. The dCA parameters were analyzed using transfer function analysis. The NCV was evaluated by eyes-open and eyes-closed (24 s each) periodically based on voice prompts. The eyes-open visual stimulation comprised silent reading of Beijing-related tourist information.
The PCA gain was lower than that of the MCA in all frequency ranges (all p < 0.05). Phase was consistent across the cerebrovascular territories. The cerebrovascular conductance index (CVCi) and mean CBFV (MV) of the PCA were significantly higher during the eyes-open than eyes-closed period (CVCi: 0.50 ± 0.12 vs. 0.38 ± 0.10; MV: 42.89 ± 8.49 vs. 32.98 ± 7.25, both p < 0.001). The PCA dCA and NVC were similar between the sexes.
We assessed two major mechanisms that maintain cerebral hemodynamic stability in healthy men and women. The visual stimulation-evoked CBFV of the PCA was significantly increased compared to that during rest, confirming the activation of NVC. Men and women have similar functions in PCA dCA and NCV.
方法:30名男性和30名年龄匹配的女性完成了dCA和NCV评估。使用经颅多普勒超声和伺服控制的体积描记器评估脑血流速度(CBFV)和平均动脉压,分别。使用传递函数分析来分析dCA参数。基于语音提示,通过周期性地睁眼和闭眼(每个24s)来评估NCV。睁大眼睛的视觉刺激包括对北京相关旅游信息的无声阅读。
结果:在所有频率范围内,PCA增益均低于MCA(所有p<0.05)。整个脑血管区域的相位一致。睁眼期间PCA的脑血管电导指数(CVCi)和平均CBFV(MV)明显高于闭眼期间(CVCi:0.50±0.12vs.0.38±0.10;MV:42.89±8.49vs.32.98±7.25,两者p<0.001)。性别之间的PCAdCA和NVC相似。
结论:我们评估了维持健康男性和女性脑血流动力学稳定的两种主要机制。与休息时相比,PCA的视觉刺激诱发的CBFV显着增加,确认NVC的激活。男性和女性在PCAdCA和NCV中具有相似的功能。