A Rare Case of Autoimmune Disorder as a Trigger for Atypical Hemolytic Uremic Syndrome.

罕见的自身免疫性疾病作为非典型溶血性尿毒症综合征的触发因素。

• 发表时间: 2024 Jan
• 来源期刊: Cureus
• DOI: 10.7759/cureus.53126
• PMID: 38420105
• 文章类型: Case Reports
• 作者列表: Pasari A,Balwani M,Gurjar P,Sejpal K,Bawankule C,Tolani P,Dubey S,Kashiv P,Bhawane A,Malde S,Gupta S

关键词: anca-associated vasculitis; antineutrophil cytoplasmic antibody; atypical hemolytic uremic syndrome; atypical hus; end-stage kidney disease; renal dysfunction; vasculitis

Abstract

Autoimmune diseases may act as a trigger for atypical hemolytic uremic syndrome (aHUS). Triggers for aHUS may include autoimmune diseases, infections, metabolic conditions, pregnancy, and transplants. aHUS-mediated injury to various organs, especially kidneys, can be life-threatening. Here, we present the case of a young female who had perinuclear antineutrophil cytoplasmic antibody (p-ANCA)-associated vasculitis and was diagnosed with aHUS. We consider underlying autoimmune p-ANCA-associated vasculitis as a trigger for aHUS in this case.

摘要

自身免疫性疾病可能是非典型溶血性尿毒综合征（aHUS）的触发因素。aHUS的触发因素可能包括自身免疫性疾病，感染,代谢条件，怀孕,和移植。HUS介导的各种器官损伤,尤其是肾脏,可能会危及生命。这里,我们介绍了1例年轻女性,她患有核周抗中性粒细胞胞浆抗体(p-ANCA)相关性血管炎,并被诊断为aHUS.在这种情况下，我们认为潜在的自身免疫性p-ANCA相关血管炎是aHUS的触发因素。