Abstract：
While local treatment of metastases is considered to be unrelated to prognosis, previous studies have suggested that local treatment of isolated lung metastases may have positive prognostic impact. We designed this prospective cohort study to investigate the clinical situation and its outcomes. We enrolled patients with fewer than 3 lung nodules suspected of being oligometastases after curative breast cancer surgery. Treatments, including local and systemic therapy, were selected by the physician and patient in consultation. The primary outcome was overall survival (OS); secondary outcomes were the efficacy and the safety of the surgery for lung oligometastases. Between May 2015 and May 2019, 14 patients were enrolled. Resection of lung nodules (metastasectomy) was performed in 11 (78.6%) of 14 patients, and one of these cases was diagnosed as primary lung cancer. Metastasectomies were all performed employing video-assisted thoracic surgery (VATS) without perioperative complications. Systemic therapies were administered to all patients except one. The respective 3-year and 5-year OS rates of patients with lung oligometastases were 91.6% and 81.5%, respectively. Progression occurred in 6 patients: 3 of the 10 with metastasectomy and all 3 without this surgical procedure. Lung metastasectomy was worthwhile as a diagnostic evaluation and may provide long-term benefit in some patients.
摘要：
虽然转移的局部治疗被认为与预后无关，先前的研究表明,局部治疗孤立性肺转移可能对预后产生积极影响.我们设计了这项前瞻性队列研究来调查临床情况及其结果。我们招募了在治愈性乳腺癌手术后怀疑是寡转移的少于3个肺结节的患者。治疗,包括局部和全身治疗，由医生和患者在咨询中选择。主要结果是总生存期（OS）；次要结果是肺寡转移手术的有效性和安全性。在2015年5月至2019年5月期间，招募了14名患者。14例患者中有11例(78.6%)进行了肺结节切除术(转移瘤切除术),其中一例被诊断为原发性肺癌。所有转移切除术均采用电视胸腔镜手术（VATS）进行，无围手术期并发症。除一名患者外，所有患者均接受全身治疗。肺寡转移患者的3年和5年OS率分别为91.6％和81.5％，分别。进展发生在6例患者中：10例中有3例进行了转移切除术，所有3例均未进行这种手术。肺转移瘤切除术值得作为诊断评估，并可能在某些患者中提供长期益处。
