Abstract：
BACKGROUND: Type 1 cryoglobulinemia is characterized by a large number of clinical signs. The lack of specificity of these signs can make diagnosis difficult. Ocular manifestations are rarely described across medical literature. Only 15 cases of ophthalmological involvement secondary to cryoglobulinaemia have been reported.
CONCLUSIONS: We report the case of a 69-year-old patient with cutaneous type 1 cryoglobulinaemia. He presented with bilateral anterior segment ischemia without retinal involvement with unilateral neovascularisation. Treatment of the B lymphocyte clone with rituximab and bendamustine and plasma exchange were initiated with successfully. Two similar cases describing ischaemic damage to the iris during type 1 cryoglobulinemia have been reported in the literature.
CONCLUSIONS: Irial ischaemia should be considered as a potential in type 1 cryoglobulinaemia.
CONCLUSIONS: We report the case of a 69-year-old patient with cutaneous type 1 cryoglobulinaemia. He presented with bilateral anterior segment ischemia without retinal involvement with unilateral neovascularisation. Treatment of the B lymphocyte clone with rituximab and bendamustine and plasma exchange were initiated with successfully. Two similar cases describing ischaemic damage to the iris during type 1 cryoglobulinemia have been reported in the literature.
CONCLUSIONS: Irial ischaemia should be considered as a potential in type 1 cryoglobulinaemia.
摘要：
背景：1型冷球蛋白血症的特征是大量的临床体征。这些体征缺乏特异性会使诊断变得困难。在医学文献中很少描述眼部表现。仅报道了15例继发于冷球蛋白血症的眼科受累。
结论：我们报告了一例69岁的皮肤1型冷球蛋白血症患者。他表现为双侧眼前节缺血，无视网膜累及单侧新生血管。成功启动了利妥昔单抗和苯达莫司汀治疗B淋巴细胞克隆和血浆置换。文献中报道了两个描述1型冷球蛋白血症期间虹膜缺血性损伤的类似病例。
结论：缺血应被认为是1型冷球蛋白血症的潜在因素。
结论：我们报告了一例69岁的皮肤1型冷球蛋白血症患者。他表现为双侧眼前节缺血，无视网膜累及单侧新生血管。成功启动了利妥昔单抗和苯达莫司汀治疗B淋巴细胞克隆和血浆置换。文献中报道了两个描述1型冷球蛋白血症期间虹膜缺血性损伤的类似病例。
结论：缺血应被认为是1型冷球蛋白血症的潜在因素。
