PDF(Pubmed)
Abstract：
In a bioeconomy that relies on synthetic DNA sequences, the ability to ensure their authenticity is critical. DNA watermarks can encode identifying data in short sequences and can be combined with error correction and encryption protocols to ensure that sequences are robust to errors and securely communicated. New digital signature techniques allow for public verification that a sequence has not been modified and can contain sufficient information for synthetic DNA to be self-documenting. In translating these techniques from bacteria to more complex genetically modified organisms (GMOs), special considerations must be made to allow for public verification of these products. We argue that these approaches should be widely implemented to assert authorship, increase the traceability, and detect the unauthorized use of synthetic DNA.
摘要：
在依赖合成DNA序列的生物经济中，确保其真实性的能力至关重要。DNA水印可以编码短序列中的识别数据，并且可以与纠错和加密协议相结合，以确保序列对错误具有鲁棒性并安全地进行通信。新的数字签名技术允许公开验证序列尚未被修改，并且可以包含足够的信息以供合成DNA进行自我记录。在将这些技术从细菌转化为更复杂的转基因生物（GMOs）时，必须特别考虑，以便对这些产品进行公开验证。我们认为，应该广泛实施这些方法来维护作者身份，增加可追溯性，并检测合成DNA的未经授权的使用。
