Abstract：
BACKGROUND: Magnetic resonance imaging (MRI) has demonstrated high levels of tissue contrast, accuracy and reproducibility in evaluating posterior uveal melanoma. Owing to smaller size, the role of MRI in detecting and characterising iris melanoma has not yet been explored.
OBJECTIVE: To develop a protocol to image iris melanoma and describe the MRI characteristics of histopathological-confirmed iris melanoma.
METHODS: An optimised MRI protocol, using a 3T MRI scanner and a 32-channel head coil, was developed to image iris tumours. A prospective, single-centre, 12-month study was conducted on all patients with lesions suspicious for iris melanoma. All patients were offered an MRI scan in addition to the standardised clinical procedures. Image quality comparison was made with existing clinical investigations. Iris melanoma characteristics on MRI are described.
RESULTS: A successful optimised MRI scan protocol was developed that was able to detect and characterise iris melanoma. One normal participant and five patients with subsequent histopathological-confirmed iris melanoma (n = 6) were recruited. Four patients completed the full MRI sequence. All iris melanoma were detected on at least one T1- or T2-weighted images. When compared to the vitreous, all iris melanomas demonstrated hyper-intensity on T1-weighted images and hypo-intensity on T2-weighted images. On T1-mapping, T1-values of iris melanoma demonstrated an inverse relationship with the degree of tumour pigmentation.
CONCLUSIONS: This study highlights an optimised, easily reproducible MRI scan protocol to image iris melanoma. Numerous MR imaging characteristics of iris melanoma are reported for the first time and a potential non-invasive tumour biomarker is described.
OBJECTIVE: To develop a protocol to image iris melanoma and describe the MRI characteristics of histopathological-confirmed iris melanoma.
METHODS: An optimised MRI protocol, using a 3T MRI scanner and a 32-channel head coil, was developed to image iris tumours. A prospective, single-centre, 12-month study was conducted on all patients with lesions suspicious for iris melanoma. All patients were offered an MRI scan in addition to the standardised clinical procedures. Image quality comparison was made with existing clinical investigations. Iris melanoma characteristics on MRI are described.
RESULTS: A successful optimised MRI scan protocol was developed that was able to detect and characterise iris melanoma. One normal participant and five patients with subsequent histopathological-confirmed iris melanoma (n = 6) were recruited. Four patients completed the full MRI sequence. All iris melanoma were detected on at least one T1- or T2-weighted images. When compared to the vitreous, all iris melanomas demonstrated hyper-intensity on T1-weighted images and hypo-intensity on T2-weighted images. On T1-mapping, T1-values of iris melanoma demonstrated an inverse relationship with the degree of tumour pigmentation.
CONCLUSIONS: This study highlights an optimised, easily reproducible MRI scan protocol to image iris melanoma. Numerous MR imaging characteristics of iris melanoma are reported for the first time and a potential non-invasive tumour biomarker is described.
摘要：
背景：磁共振成像（MRI）显示出高水平的组织对比度，评估后葡萄膜黑色素瘤的准确性和可重复性。由于尺寸较小，MRI在检测和表征虹膜黑色素瘤中的作用尚未被研究.
目的：制定虹膜黑色素瘤成像方案，并描述组织病理学证实的虹膜黑色素瘤的MRI特征。
方法：优化的MRI方案，使用3TMRI扫描仪和32通道头部线圈，被开发来成像虹膜肿瘤。一个潜在的，单中心,对所有可疑为虹膜黑色素瘤的患者进行了为期12个月的研究。除标准化的临床程序外，所有患者均接受了MRI扫描。图像质量与现有临床研究进行了比较。描述了MRI上的虹膜黑色素瘤特征。
结果：开发了一种成功的优化MRI扫描方案，能够检测和表征虹膜黑色素瘤。招募了一名正常参与者和五名随后经组织病理学证实的虹膜黑色素瘤患者（n=6）。四名患者完成了完整的MRI序列。在至少一个T1或T2加权图像上检测到所有虹膜黑色素瘤。与玻璃体相比，所有虹膜黑素瘤在T1加权图像上表现为高强度,在T2加权图像上表现为低强度.在T1映射中，虹膜黑色素瘤的T1值与肿瘤色素沉着的程度成反比。
结论：这项研究强调了优化的，易于重复的MRI扫描协议来成像虹膜黑色素瘤。首次报道了虹膜黑色素瘤的许多MR成像特征，并描述了一种潜在的非侵入性肿瘤生物标志物。
目的：制定虹膜黑色素瘤成像方案，并描述组织病理学证实的虹膜黑色素瘤的MRI特征。
方法：优化的MRI方案，使用3TMRI扫描仪和32通道头部线圈，被开发来成像虹膜肿瘤。一个潜在的，单中心,对所有可疑为虹膜黑色素瘤的患者进行了为期12个月的研究。除标准化的临床程序外，所有患者均接受了MRI扫描。图像质量与现有临床研究进行了比较。描述了MRI上的虹膜黑色素瘤特征。
结果：开发了一种成功的优化MRI扫描方案，能够检测和表征虹膜黑色素瘤。招募了一名正常参与者和五名随后经组织病理学证实的虹膜黑色素瘤患者（n=6）。四名患者完成了完整的MRI序列。在至少一个T1或T2加权图像上检测到所有虹膜黑色素瘤。与玻璃体相比，所有虹膜黑素瘤在T1加权图像上表现为高强度,在T2加权图像上表现为低强度.在T1映射中，虹膜黑色素瘤的T1值与肿瘤色素沉着的程度成反比。
结论：这项研究强调了优化的，易于重复的MRI扫描协议来成像虹膜黑色素瘤。首次报道了虹膜黑色素瘤的许多MR成像特征，并描述了一种潜在的非侵入性肿瘤生物标志物。
