Abstract：
Urinary stones are a growing disease that results from pathological biomineralization. Cassia fistula Lin. is traditionally used to treat urinary stones. However, no scientific evidence is available to prove its antilithiatic effect. This study evaluates the antilithiatic potential of aqueous and ethanolic extract of Cassia fistula Lin. fruit (Cff) against calcium oxalate kidney stones. Forty-two male Wistar rats were divided into seven groups (n = 6/group): Group I (control), Group II (rats treated with ethylene glycol and ammonium chloride developed nephrolithiasis after 28 days), Group III (lithiatic rats receiving distilled water for 30 days), Group IV and V (lithiatic rats receiving aqueous extract of Cff at doses of 1 and 100 mg/kg body weight for 30 days, respectively) and Group VI and VII (lithiatic rats receiving ethanolic extract of Cff at doses of 1 and 100 mg/kg body weight for 30 days, respectively). Some parameters of urine and serum, and also renal oxidative stress and histopathology were used to determine the antilithiatic effect of aqueous and ethanolic extract of Cff. Therefore, the types of extracts of Cff improved abnormal levels of urine, serum, and renal oxidative stress and histopathology parameters. This antilithiatic effect of aqueous and ethanolic extracts of Cff, can be attributed to the anti-crystallization and antioxidant properties of the extracts and the ability to improve urine and serum biochemistry. RESEARCH HIGHLIGHTS: Ethylene glycol and ammonium chloride-induced urolithiasis, aggregation of calcium oxalate deposits, increase of some urinary and serum parameters, relative kidney weight, kidney size and MDA activity, decrease of some urinary parameters, relative body weight and SOD activity. Aqueous and ethanolic extracts of Cassia fistula Lin. lead to the treatment of urolithic rats by decreasing levels of urinary oxalate, phosphate, urea, serum urea, uric acid, creatinine, calcium, phosphate, MDA, kidney weight and kidney size, increasing levels of urinary calcium, creatinine, magnesium, citrate, body weight and SOD activity in the kidney, eliminating CaOx deposition (esp. ethanolic extract).
摘要：
尿路结石是一种由病理性生物矿化引起的疾病。决明子瘘林。传统上用于治疗泌尿系结石。然而,没有科学证据证明其抗结石作用。这项研究评估了决明子瘘管Lin的水性和乙醇提取物的抗结石潜力。果实(Cff)对抗草酸钙肾结石。将42只雄性Wistar大鼠分为7组（n=6/组）：I组（对照组），II组（用乙二醇和氯化铵治疗的大鼠在28天后出现肾结石），第III组（接受蒸馏水30天的结石大鼠），组IV和V（接受剂量为1和100mg/kg体重的Cff水提取物30天的结石大鼠，分别）和VI和VII组（接受剂量为1和100mg/kg体重的Cff乙醇提取物30天的结石大鼠，分别)。尿液和血清的一些参数，以及肾脏氧化应激和组织病理学用于确定Cff的水性和乙醇提取物的抗结石作用。因此,Cff提取物的类型改善了尿液的异常水平，血清,和肾脏氧化应激和组织病理学参数。Cff的水性和乙醇提取物的这种抗锂作用，可归因于提取物的抗结晶和抗氧化特性以及改善尿液和血清生物化学的能力。研究重点：乙二醇和氯化铵引起的尿石症，草酸钙沉积物的聚集，增加一些尿和血清参数，相对肾脏重量，肾脏大小和MDA活性，减少一些尿参数，相对体重和SOD活性。决明子瘘管林的水和乙醇提取物。导致通过降低尿草酸盐水平来治疗尿石症大鼠，磷酸盐,尿素,血清尿素,尿酸,肌酐,钙，磷酸盐,MDA,肾脏重量和肾脏大小，增加尿钙水平，肌酐,镁，柠檬酸盐体重和肾脏中的SOD活性，消除CaOx沉积(特别是乙醇提取物)。
