Abstract：
OBJECTIVE: To evaluate the sensitivity and the specificity of summating potential (SP)/action potential (AP) area under the curve (AUC) ratio by a transtympanic electrode and a click stimulus (TT-CS), SP/AP AUC ratio by an extratympanic electrode and a click stimulus (ET-CS) and SP amplitude value by a transtympanic electrode and tone burst stimulus (TT-TBS) in regard of Ménière\'s disease (MD) diagnosis. This is the first study that compares SP amplitude value performed by a TT-TBS and the SP/AP AUC ratio performed by a TT-CS.
METHODS: Retrospective comparative study.
METHODS: Ninety-five patients met the inclusion criteria for electrocochleography (ECochG) testing in a tertiary care center.
METHODS: The sensitivity and specificity of our different ECochG protocols were calculated in regard of the diagnosis of MD.
RESULTS: The patients\' mean age was 54 years old (female predominance). The sensitivity and the specificity of SP/AP area ratio by a TT-CS were 88.5% and 70.0%, respectively. On the other hand, the sensitivity and specificity for the SP amplitude value by a TT-TBS were 60.0% and 55.6%, respectively. SP/AP area ratio by TT-CS was statistically better than SP amplitude value by TT-TBS to detect MD disease (P = .016). However, no difference was identified between SP/AP area ratio by ET-CS and SP amplitude value by a TT-TBS (P = .573).
CONCLUSIONS: SP/AP area ratio by click stimulation has higher sensitivity and specificity to detect MD compared to SP amplitude value by tone burst stimulation. ECochG would be extremely useful in the diagnosis of MD if we use the SP/AP area ratio (sensitivity: 88.5%); therefore, it changes the bad reputation of ECochG sensitivity using SP/AP amplitude ratio (sensitivity: 51.7%) for the diagnosis of MD.
METHODS: Retrospective comparative study.
METHODS: Ninety-five patients met the inclusion criteria for electrocochleography (ECochG) testing in a tertiary care center.
METHODS: The sensitivity and specificity of our different ECochG protocols were calculated in regard of the diagnosis of MD.
RESULTS: The patients\' mean age was 54 years old (female predominance). The sensitivity and the specificity of SP/AP area ratio by a TT-CS were 88.5% and 70.0%, respectively. On the other hand, the sensitivity and specificity for the SP amplitude value by a TT-TBS were 60.0% and 55.6%, respectively. SP/AP area ratio by TT-CS was statistically better than SP amplitude value by TT-TBS to detect MD disease (P = .016). However, no difference was identified between SP/AP area ratio by ET-CS and SP amplitude value by a TT-TBS (P = .573).
CONCLUSIONS: SP/AP area ratio by click stimulation has higher sensitivity and specificity to detect MD compared to SP amplitude value by tone burst stimulation. ECochG would be extremely useful in the diagnosis of MD if we use the SP/AP area ratio (sensitivity: 88.5%); therefore, it changes the bad reputation of ECochG sensitivity using SP/AP amplitude ratio (sensitivity: 51.7%) for the diagnosis of MD.
摘要：
目的：通过跨电极和点击刺激（TT-CS）评估求和电位（SP）/动作电位（AP）曲线下面积（AUC）比率的敏感性和特异性，关于梅尼埃病（MD）的诊断，通过鼓室外电极和点击刺激（ET-CS）的SP/APAUC比率以及通过跨电极和音调脉冲刺激（TT-TBS）的SP振幅值。这是比较由TT-TBS执行的SP振幅值和由TT-CS执行的SP/APAUC比率的第一项研究。
方法：回顾性对比研究。
方法：95例患者符合三级护理中心的耳蜗电图（ECochG）检测的纳入标准。
方法：计算了我们不同的ECochG方案在诊断MD方面的敏感性和特异性。
结果：患者平均年龄54岁（以女性为主）。TT-CS对SP/AP面积比的敏感性和特异性分别为88.5%和70.0%,分别。另一方面,TT-TBS对SP振幅值的敏感性和特异性分别为60.0%和55.6%，分别。TT-CS的SP/AP面积比在统计学上优于TT-TBS的SP振幅值，以检测MD疾病（P=0.016）。然而,ET-CS的SP/AP面积比和TT-TBS的SP振幅值之间没有差异（P=.573）。
结论：通过点击刺激的SP/AP面积比与通过音调突发刺激的SP振幅值相比，对检测MD具有更高的灵敏度和特异性。如果我们使用SP/AP面积比（灵敏度：88.5％），ECochG将在MD的诊断中非常有用；因此，使用SP/AP振幅比（灵敏度：51.7％）诊断MD改变了ECochG敏感性的不良声誉。
方法：回顾性对比研究。
方法：95例患者符合三级护理中心的耳蜗电图（ECochG）检测的纳入标准。
方法：计算了我们不同的ECochG方案在诊断MD方面的敏感性和特异性。
结果：患者平均年龄54岁（以女性为主）。TT-CS对SP/AP面积比的敏感性和特异性分别为88.5%和70.0%,分别。另一方面,TT-TBS对SP振幅值的敏感性和特异性分别为60.0%和55.6%，分别。TT-CS的SP/AP面积比在统计学上优于TT-TBS的SP振幅值，以检测MD疾病（P=0.016）。然而,ET-CS的SP/AP面积比和TT-TBS的SP振幅值之间没有差异（P=.573）。
结论：通过点击刺激的SP/AP面积比与通过音调突发刺激的SP振幅值相比，对检测MD具有更高的灵敏度和特异性。如果我们使用SP/AP面积比（灵敏度：88.5％），ECochG将在MD的诊断中非常有用；因此，使用SP/AP振幅比（灵敏度：51.7％）诊断MD改变了ECochG敏感性的不良声誉。
