PDF(Pubmed)
Abstract：
Hematopoietic stem cells (HSCs) undergo self-renewal and differentiation in the bone marrow, which is tightly regulated by cues from the microenvironment. The gut microbiota, a dynamic community residing on the mucosal surface of vertebrates, plays a crucial role in maintaining host health. Recent evidence suggests that the gut microbiota influences HSCs differentiation by modulating the bone marrow microenvironment through microbial products. This paper comprehensively analyzes the impact of the gut microbiota on hematopoiesis and its effect on HSCs fate and differentiation by modifying the bone marrow microenvironment, including mechanical properties, inflammatory signals, bone marrow stromal cells, and metabolites. Furthermore, we discuss the involvement of the gut microbiota in the development of hematologic malignancies, such as leukemia, multiple myeloma, and lymphoma.
摘要：
造血干细胞（HSC）在骨髓中经历自我更新和分化，受到来自微环境的线索的严格调控。肠道微生物群，居住在脊椎动物粘膜表面的动态群落，在维持宿主健康中起着至关重要的作用。最近的证据表明，肠道微生物群通过微生物产物调节骨髓微环境来影响HSC的分化。本文综合分析了肠道菌群对造血的影响及其通过改变骨髓微环境对HSCs命运和分化的影响,包括机械性能，炎症信号，骨髓基质细胞,和代谢物。此外，我们讨论了肠道微生物群参与血液系统恶性肿瘤的发展，比如白血病，多发性骨髓瘤,和淋巴瘤。
