PDF(Pubmed)
Abstract：
Suppressor of cytokine signaling 1 (SOCS1) is a potent regulator immune cell responses and a proven tumor suppressor. Inhibition of SOCS1 in T cells can boost antitumor immunity, whereas its loss in tumor cells increases tumor aggressivity. Investigations into the tumor suppression mechanisms so far focused on tumor cell-intrinsic functions of SOCS1. However, it is possible that SOCS1 expression in tumor cells also regulate antitumor immune responses in a cell-extrinsic manner via direct and indirect mechanisms. Here, we discuss the evidence supporting the latter, and its implications for antitumor immunity.
摘要：
细胞因子信号传导抑制因子1(SOCS1)是一种有效的调节免疫细胞应答和已证实的肿瘤抑制因子。在T细胞中抑制SOCS1可以增强抗肿瘤免疫力，而它在肿瘤细胞中的损失增加了肿瘤的侵袭性。迄今为止，对肿瘤抑制机制的研究集中在SOCS1的肿瘤细胞固有功能上。然而,SOCS1在肿瘤细胞中的表达也可能通过直接和间接机制以细胞外在方式调节抗肿瘤免疫应答。这里,我们讨论支持后者的证据，及其对抗肿瘤免疫的影响。
