%0 Journal Article
%T SOCS1 expression in cancer cells: potential roles in promoting antitumor immunity.
%A Ilangumaran S
%A Gui Y
%A Shukla A
%A Ramanathan S
%J Front Immunol
%V 15
%N 0
%D 2024
%M 38415248
%F 8.786
%R 10.3389/fimmu.2024.1362224
%X Suppressor of cytokine signaling 1 (SOCS1) is a potent regulator immune cell responses and a proven tumor suppressor. Inhibition of SOCS1 in T cells can boost antitumor immunity, whereas its loss in tumor cells increases tumor aggressivity. Investigations into the tumor suppression mechanisms so far focused on tumor cell-intrinsic functions of SOCS1. However, it is possible that SOCS1 expression in tumor cells also regulate antitumor immune responses in a cell-extrinsic manner via direct and indirect mechanisms. Here, we discuss the evidence supporting the latter, and its implications for antitumor immunity.