Abstract：
BACKGROUND: The hypothalamic-pituitary-gonadal axis\'s transient activity in infancy, i.e, minipuberty, is considered crucial for male reproductive function. Historically, minipuberty has been considered a passive response triggered by the withdrawal of placental steroids at birth. However, given its potential link to adult reproductive function, we hypothesize that minipuberty is a partially genetically regulated process, suggesting a link between the genetic architecture of reproductive hormone concentrations across lifespan.
OBJECTIVE: To investigate the association of UK Biobank Study-based polygenic scores (PGS) of adult total testosterone (T) and sex hormone-binding globulin (SHBG) concentrations with trajectories of reproductive hormones concentrations in male infants.
METHODS: Prospective, longitudinal birth cohort (The COPENHAGEN Minipuberty Study, 2016-2018, ClinTrial: NCT02784184). Individual PGSs in male infants derived from published literature were calculated for total T and SHBG. The associations with mean SD scores (SDS) of reproductive hormone concentrations in infancy were tested.
METHODS: Population-based.
METHODS: Healthy, male, term, singleton newborns were followed with repeated clinical examinations including blood sampling during a 1-year follow-up (n = 109).
METHODS: Circulating reproductive hormone concentrations.
RESULTS: T-PGSadult were significant associated with mean T-SDSinfancy, mean SHBG-SDSinfancy, and mean LH-SDSinfancy (P = .02, <.001 and .03, with r2 = 0.05, 0.21 and 0.04, respectively). SHBG-PGSadult was significantly associated with mean SHBG-SDSinfancy (P < .001, r2 = 0.18). T-PGSadult explained 5% and 21% of the phenotypic variation in infancy of mean T-SDSinfancy and SHBG-SDSinfancy, respectively.
CONCLUSIONS: Our findings suggest that the genetic architecture underlying total T and SHBG in adults also associates with hormone concentrations and their trajectories during infancy.
OBJECTIVE: To investigate the association of UK Biobank Study-based polygenic scores (PGS) of adult total testosterone (T) and sex hormone-binding globulin (SHBG) concentrations with trajectories of reproductive hormones concentrations in male infants.
METHODS: Prospective, longitudinal birth cohort (The COPENHAGEN Minipuberty Study, 2016-2018, ClinTrial: NCT02784184). Individual PGSs in male infants derived from published literature were calculated for total T and SHBG. The associations with mean SD scores (SDS) of reproductive hormone concentrations in infancy were tested.
METHODS: Population-based.
METHODS: Healthy, male, term, singleton newborns were followed with repeated clinical examinations including blood sampling during a 1-year follow-up (n = 109).
METHODS: Circulating reproductive hormone concentrations.
RESULTS: T-PGSadult were significant associated with mean T-SDSinfancy, mean SHBG-SDSinfancy, and mean LH-SDSinfancy (P = .02, <.001 and .03, with r2 = 0.05, 0.21 and 0.04, respectively). SHBG-PGSadult was significantly associated with mean SHBG-SDSinfancy (P < .001, r2 = 0.18). T-PGSadult explained 5% and 21% of the phenotypic variation in infancy of mean T-SDSinfancy and SHBG-SDSinfancy, respectively.
CONCLUSIONS: Our findings suggest that the genetic architecture underlying total T and SHBG in adults also associates with hormone concentrations and their trajectories during infancy.
摘要：
背景：婴儿期下丘脑-垂体-性腺轴的短暂活动，即，青春期,被认为对男性生殖功能至关重要。历史上,小青春期被认为是出生时胎盘类固醇戒断引发的被动反应。然而,考虑到它与成人生殖功能的潜在联系，我们假设青春期是一个部分基因调控的过程，表明生殖激素浓度在整个生命周期中的遗传结构之间存在联系。
目的：研究基于UKBiobank研究的成人总睾酮（T）和性激素结合球蛋白（SHBG）浓度的多基因评分（PGS）与男性婴儿生殖激素浓度的关系。
方法：前瞻性，纵向出生队列(哥本哈根小青春期研究，2016-2018，临床试验：NCT02784184）。从发表的文献中得出的男婴个体PGS计算总T和SHBG。测试了婴儿期生殖激素浓度与平均SD评分（SDS）的相关性。
方法：以人口为基础。
方法：健康，男性,term,单胎新生儿在1年随访期间接受重复的临床检查,包括采血(n=109).
方法：循环生殖激素浓度。
结果：平均SHBG-SDS婴儿期，和平均LH-SDS婴儿期（P=.02，<.001和.03，r2分别=0.05，0.21和0.04）。SHBG-PGSmadal与平均SHBG-SDSinfy显著相关(P<.001,r2=0.18)。T-PGSmadal解释了平均T-SDS婴儿期和SHBG-SDS婴儿期的5％和21％的表型变异，分别。
结论：我们的研究结果表明，成人总T和SHBG的遗传结构也与婴儿时期的激素浓度及其轨迹相关。
目的：研究基于UKBiobank研究的成人总睾酮（T）和性激素结合球蛋白（SHBG）浓度的多基因评分（PGS）与男性婴儿生殖激素浓度的关系。
方法：前瞻性，纵向出生队列(哥本哈根小青春期研究，2016-2018，临床试验：NCT02784184）。从发表的文献中得出的男婴个体PGS计算总T和SHBG。测试了婴儿期生殖激素浓度与平均SD评分（SDS）的相关性。
方法：以人口为基础。
方法：健康，男性,term,单胎新生儿在1年随访期间接受重复的临床检查,包括采血(n=109).
方法：循环生殖激素浓度。
结果：平均SHBG-SDS婴儿期，和平均LH-SDS婴儿期（P=.02，<.001和.03，r2分别=0.05，0.21和0.04）。SHBG-PGSmadal与平均SHBG-SDSinfy显著相关(P<.001,r2=0.18)。T-PGSmadal解释了平均T-SDS婴儿期和SHBG-SDS婴儿期的5％和21％的表型变异，分别。
结论：我们的研究结果表明，成人总T和SHBG的遗传结构也与婴儿时期的激素浓度及其轨迹相关。
