Abstract：
There is growing consensus that diagnostic labels are insufficient to describe the individual child\'s psychiatric profile, much less inform the precise combination of interventions that will minimize the impact of risk and/or bolster protective factors over the course of a particular child\'s development. Moreover, investigations of neurobiological and genetic mechanisms associated with psychopathology have revealed considerable cross-diagnostic overlap, undermining the validity of models that propose a 1:1 relationship between risk and psychiatric disorder. Accordingly, recent publications have advocated for neurodevelopmental models that utilize trait-based measurement, as well as increased emphasis on integration of biological and experiential mechanisms. Despite an expanding body of literature supporting this conceptual shift, the practical implications remain unclear. In this special issue, we compile a collection of novel empirical research papers and reviews that build on the trans-diagnostic principles of the RDoC framework.
摘要：
越来越多的共识是，诊断标签不足以描述个别儿童的精神病概况，更不用说告知干预措施的精确组合，这些干预措施将在特定儿童的发育过程中最小化风险的影响和/或增强保护因素。此外，对与精神病理学相关的神经生物学和遗传机制的研究揭示了相当大的交叉诊断重叠，破坏了提出风险与精神疾病1：1关系的模型的有效性。因此，最近的出版物提倡利用基于特征的测量的神经发育模型，以及越来越重视生物和经验机制的整合。尽管越来越多的文献支持这种概念转变，实际影响尚不清楚。在本期特刊中,我们编写了一系列新颖的实证研究论文，并回顾了RDoC框架的跨诊断原则。
