关键词: antibacterial bone regeneration dressing self‐healing wound closure

Mesh : Bone Regeneration / drug effects Animals Anti-Bacterial Agents / pharmacology chemistry Wound Healing / drug effects Bandages Humans Rats Surgical Wound Dehiscence / therapy prevention & control Rats, Sprague-Dawley Osteogenesis / drug effects

来  源:   DOI:10.1002/adhm.202304128

Abstract:
Guided bone regeneration (GBR) is a well-established technique for preserving and enhancing alveolar ridge structures. Success in GBR relies on fulfilling the Primary wound closure, Angiogenesis, Space maintenance, and Stability (PASS) principles. Conventional methods, involving titanium meshes and sutures, have drawbacks, including the need for secondary removal and customization challenges. To address these issues, an innovative multifunctional GBR dressing (MGD) based on self-healing elastomer (PUIDS) is introduced. MGD provides sutureless wound closure, prevents food particle accumulation, and maintains a stable environment for bone growth. It offers biocompatibility, bactericidal properties, and effectiveness in an oral GBR model. In summary, MGD provides a reliable, stable osteogenic environment for GBR, aligning with PASS principles and promoting superior post-surgery bone regeneration.
摘要:
引导骨再生(GBR)是一种用于保存和增强牙槽骨结构的成熟技术。GBR的成功依赖于完成初次伤口闭合,血管生成,空间维护,和稳定性(PASS)原则。常规方法,包括钛网和缝线,有缺点,包括二次移除和定制挑战的需要。为了解决这些问题,介绍了一种基于自修复弹性体(PUIDS)的创新多功能GBR敷料(MGD)。MGD提供无缝合伤口闭合,防止食物颗粒积聚,维持骨骼生长的稳定环境。它提供了生物相容性,杀菌性能,以及在口腔GBR模型中的有效性。总之,MGD提供了一个可靠的,GBR稳定的成骨环境,符合PASS原则,促进优越的术后骨再生。本文受版权保护。保留所有权利。
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