Abstract：
Seven new polyketides including three chromone derivatives (1-3) and four linear ones incorporating a tetrahydrofuran ring (4-7), along with three known compounds (8-10), were obtained from the fermentation of an endophytic fungus (Chaetomium sp. UJN-EF006) isolated from the leaves of Vaccinium bracteatum. The structures of these fungal metabolites have been elucidated by spectroscopic means including MS, NMR and electronic circular dichroism. A preliminary anti-inflammatory screening with the lipopolysaccharide (LPS) induced RAW264.7 cell model revealed moderate NO production inhibitory activity for compounds 1 and 4. In addition, the expression of three LPS-induced inflammatory factors IL-6, iNOS and COX-2 was also blocked by 1 and 4.
摘要：
七个新的聚酮化合物，包括三个色酮衍生物（1-3）和四个包含四氢呋喃环的线性衍生物（4-7），连同三个已知的化合物（8-10），是从内生真菌的发酵中获得的（Chaetomiumsp.UJN-EF006）从越桔叶中分离。这些真菌代谢物的结构已通过光谱手段阐明，包括MS，NMR和电子圆二色性。用脂多糖(LPS)诱导的RAW264.7细胞模型的初步抗炎筛选显示化合物1和4具有中等的NO产生抑制活性。此外,LPS诱导的三种炎症因子IL-6、iNOS和COX-2的表达也被1和4阻断。
