Abstract：
OBJECTIVE: The prognostic value of depth of invasion (DOI) in oral squamous cell cancer carcinoma and cutaneous melanoma is well established, while there is a lack of reports investigating the role of DOI in laryngeal cancer. This study aims to explore the association of glottic cancer DOI with other established pathological risk factors and nodal metastasis and evaluate the feasibility of measuring DOI preoperatively using tomographic imaging.
METHODS: The medical records of glottic cancer patients treated between 2015 and 2020 in a single tertiary referral center were screened retrospectively. Pathologically measured DOI (pDOI) value was also reviewed and registered. Preoperative computer tomography (CT) was used to obtain the radiological DOI (rDOI) measured by two dedicated radiologists. Their inter-rated agreement was assessed and the correlation between pDOI and rDOI was calculated. pDOI association with the main pathology report features was assessed with univariable analysis. Cox univariable and multivariable models were used to explore the role of pDOI on survival.
RESULTS: Ninety-one patients had pDOI data available, of which 59 also had rDOI data. A strong concordance between the two radiologists was found (concordance correlation coefficient = 0.96); rDOI and pDOI were highly and significantly correlated (R = 0.85; p < 0.001). pDOI was significantly higher in patients with perineural invasion (PNI; p < 0.001), lymphovascular invasion (LVI; p < 0.001), and nodal metastasis (p < 0.001). pDOI was associated with disease-free survival at univariable analysis (p = 0.04) while it did not show a significant impact (p = 0.10) at multivariable analysis.
CONCLUSIONS: Glottic carcinoma DOI correlates with PNI, LVI, and nodal metastasis and it can be reliably assessed in a preoperative setting using CT imaging.
METHODS: 3 Laryngoscope, 134:3230-3237, 2024.
METHODS: The medical records of glottic cancer patients treated between 2015 and 2020 in a single tertiary referral center were screened retrospectively. Pathologically measured DOI (pDOI) value was also reviewed and registered. Preoperative computer tomography (CT) was used to obtain the radiological DOI (rDOI) measured by two dedicated radiologists. Their inter-rated agreement was assessed and the correlation between pDOI and rDOI was calculated. pDOI association with the main pathology report features was assessed with univariable analysis. Cox univariable and multivariable models were used to explore the role of pDOI on survival.
RESULTS: Ninety-one patients had pDOI data available, of which 59 also had rDOI data. A strong concordance between the two radiologists was found (concordance correlation coefficient = 0.96); rDOI and pDOI were highly and significantly correlated (R = 0.85; p < 0.001). pDOI was significantly higher in patients with perineural invasion (PNI; p < 0.001), lymphovascular invasion (LVI; p < 0.001), and nodal metastasis (p < 0.001). pDOI was associated with disease-free survival at univariable analysis (p = 0.04) while it did not show a significant impact (p = 0.10) at multivariable analysis.
CONCLUSIONS: Glottic carcinoma DOI correlates with PNI, LVI, and nodal metastasis and it can be reliably assessed in a preoperative setting using CT imaging.
METHODS: 3 Laryngoscope, 134:3230-3237, 2024.
摘要：
目的：口腔鳞状细胞癌和皮肤黑色素瘤的浸润深度（DOI）的预后价值已得到证实，虽然缺乏研究DOI在喉癌中的作用的报道。本研究旨在探讨声门癌DOI与其他已建立的病理危险因素和淋巴结转移的关系，并评估术前使用断层成像技术测量DOI的可行性。
方法：回顾性筛选了2015年至2020年在一个三级转诊中心接受治疗的声门癌患者的病历。病理测量的DOI(pDOI)值也被审查和登记。术前计算机断层扫描（CT）用于获得由两名专门的放射科医生测量的放射学DOI（rDOI）。评估了他们的等级间一致性，并计算了pDOI和rDOI之间的相关性。用单变量分析评估pDOI与主要病理报告特征的关联。使用Cox单变量和多变量模型来探讨pDOI对生存的作用。
结果：91例患者有pDOI数据，其中59人也有rDOI数据。发现两位放射科医生之间存在很强的一致性（一致性相关系数=0.96）；rDOI和pDOI高度显着相关（R=0.85；p<0.001）。神经周侵犯患者的pDOI明显更高（PNI;p<0.001），淋巴管浸润（LVI；p<0.001），淋巴结转移（p<0.001）。在单变量分析中,pDOI与无病生存率相关(p=0.04),而在多变量分析中,pDOI未显示显著影响(p=0.10)。
结论：喉癌DOI与PNI相关，LVI,和淋巴结转移，可以在术前使用CT成像可靠地评估。
方法：3喉镜，2024.
方法：回顾性筛选了2015年至2020年在一个三级转诊中心接受治疗的声门癌患者的病历。病理测量的DOI(pDOI)值也被审查和登记。术前计算机断层扫描（CT）用于获得由两名专门的放射科医生测量的放射学DOI（rDOI）。评估了他们的等级间一致性，并计算了pDOI和rDOI之间的相关性。用单变量分析评估pDOI与主要病理报告特征的关联。使用Cox单变量和多变量模型来探讨pDOI对生存的作用。
结果：91例患者有pDOI数据，其中59人也有rDOI数据。发现两位放射科医生之间存在很强的一致性（一致性相关系数=0.96）；rDOI和pDOI高度显着相关（R=0.85；p<0.001）。神经周侵犯患者的pDOI明显更高（PNI;p<0.001），淋巴管浸润（LVI；p<0.001），淋巴结转移（p<0.001）。在单变量分析中,pDOI与无病生存率相关(p=0.04),而在多变量分析中,pDOI未显示显著影响(p=0.10)。
结论：喉癌DOI与PNI相关，LVI,和淋巴结转移，可以在术前使用CT成像可靠地评估。
方法：3喉镜，2024.
