Abstract：
The prevalence of choroidal naevi is common and has been found to be up to 10%. Little is known regarding the optical properties of choroidal naevi. A novel hyperspectral eye fundus camera was used to investigate choroidal naevi\'s optical density spectra in the retina.
In an ophthalmology clinic setting, patients with choroidal naevi were included in the study. Visual acuity and pressure were tested. Following mydriatics, optical coherence tomography and fundus photography were taken as a reference, after which a hyperspectral image with 12 nm spectral resolution at 450-700 nm was taken. The optical density spectra was measured across the area of the naevus.
Nine patients with 11 naevi were examined. The visual acuity was not affected by any of the naevi. All the naevi were flat as measured either with the optical coherence tomography and/or on inspection, and only one naevi had a risk factor (orange pigmentation). The Wasserstein distance between the background and the naevi was higher at 695 nm compared to 555 nm (p = .002). The naevi could be grouped into three clusters based on the extracted optical density spectra.
Choroidal naevi are better visible in longer wavelengths compared to shorter wavelengths. This finding can be used to contour and follow choroidal naevi. Choroidal naevi expose different optical density spectra that can be grouped into three different clusters. One of these clusters has an optical density spectra resembling the absorption spectra of lipofuscin, which may indicate the content of this pigment.
In an ophthalmology clinic setting, patients with choroidal naevi were included in the study. Visual acuity and pressure were tested. Following mydriatics, optical coherence tomography and fundus photography were taken as a reference, after which a hyperspectral image with 12 nm spectral resolution at 450-700 nm was taken. The optical density spectra was measured across the area of the naevus.
Nine patients with 11 naevi were examined. The visual acuity was not affected by any of the naevi. All the naevi were flat as measured either with the optical coherence tomography and/or on inspection, and only one naevi had a risk factor (orange pigmentation). The Wasserstein distance between the background and the naevi was higher at 695 nm compared to 555 nm (p = .002). The naevi could be grouped into three clusters based on the extracted optical density spectra.
Choroidal naevi are better visible in longer wavelengths compared to shorter wavelengths. This finding can be used to contour and follow choroidal naevi. Choroidal naevi expose different optical density spectra that can be grouped into three different clusters. One of these clusters has an optical density spectra resembling the absorption spectra of lipofuscin, which may indicate the content of this pigment.
摘要：
■脉络膜痣的患病率很常见，已发现高达10％。关于脉络膜痣的光学性质知之甚少。一种新型的高光谱眼底相机用于研究脉络膜痣在视网膜中的光密度光谱。
■在眼科诊所环境中，脉络膜痣患者被纳入研究.测试视敏度和压力。在散瞳之后，光学相干断层扫描和眼底摄影作为参考，之后，在450-700nm处拍摄具有12nm光谱分辨率的高光谱图像。在痣的整个区域测量光密度光谱。
■检查了9例11naevi患者。视敏度不受任何naevi的影响。通过光学相干断层扫描和/或检查，所有的奈维都是平坦的，只有一个纳维有危险因素（橙色色素沉着）。背景和naevi之间的Wasserstein距离在695nm处高于555nm(p=.002)。根据提取的光密度光谱，可以将naevi分为三个簇。
■脉络膜痣在更长的波长下比在更短的波长下更好地可见。此发现可用于轮廓和跟踪脉络膜痣。脉络膜痣暴露了不同的光密度光谱，可以分为三个不同的簇。这些团簇之一的光密度光谱类似于脂褐素的吸收光谱，这可能表明这种颜料的含量。
■在眼科诊所环境中，脉络膜痣患者被纳入研究.测试视敏度和压力。在散瞳之后，光学相干断层扫描和眼底摄影作为参考，之后，在450-700nm处拍摄具有12nm光谱分辨率的高光谱图像。在痣的整个区域测量光密度光谱。
■检查了9例11naevi患者。视敏度不受任何naevi的影响。通过光学相干断层扫描和/或检查，所有的奈维都是平坦的，只有一个纳维有危险因素（橙色色素沉着）。背景和naevi之间的Wasserstein距离在695nm处高于555nm(p=.002)。根据提取的光密度光谱，可以将naevi分为三个簇。
■脉络膜痣在更长的波长下比在更短的波长下更好地可见。此发现可用于轮廓和跟踪脉络膜痣。脉络膜痣暴露了不同的光密度光谱，可以分为三个不同的簇。这些团簇之一的光密度光谱类似于脂褐素的吸收光谱，这可能表明这种颜料的含量。
