Abstract：
Human milk banks have been established to provide human milk to preterm infants who are unable to obtain milk from their mothers. Donor screening methods vary, and prospective donors are commonly screened for drug and recreational substance use through behavioral screening. Although the risk of illegal drug consumption in Japan is extremely low, caffeine may be consumed unknowingly and can be found in human milk. To date, only a few reports have been conducted on the concentration of caffeine in donor milk.
This study aimed to examine the pre-pasteurization levels of caffeine in human milk donated to a milk bank in Japan.
This was a cross-sectional, observational study of caffeine concentrations in human milk donated to a human milk bank in Japan. Caffeine concentration in the donor milk was measured using high-performance liquid chromatography.
Caffeine was detected in 70% of the donor milk samples (N = 350). The median (range) of caffeine concentration was 0.46 [< 0.10, 7.54] mg/L, and 64.0% of the samples had less than 1 mg/L of caffeine. The caffeine concentration varied widely among as well as within individuals.
The average caffeine concentration in Japanese donor milk samples was higher than that previously reported in samples from Spain, but the range was similar. Donors should be informed that caffeine intake should be within a moderate range, to further increase the safety of donor milk.
This study aimed to examine the pre-pasteurization levels of caffeine in human milk donated to a milk bank in Japan.
This was a cross-sectional, observational study of caffeine concentrations in human milk donated to a human milk bank in Japan. Caffeine concentration in the donor milk was measured using high-performance liquid chromatography.
Caffeine was detected in 70% of the donor milk samples (N = 350). The median (range) of caffeine concentration was 0.46 [< 0.10, 7.54] mg/L, and 64.0% of the samples had less than 1 mg/L of caffeine. The caffeine concentration varied widely among as well as within individuals.
The average caffeine concentration in Japanese donor milk samples was higher than that previously reported in samples from Spain, but the range was similar. Donors should be informed that caffeine intake should be within a moderate range, to further increase the safety of donor milk.
摘要：
■已经建立了母乳银行，为无法从母亲那里获得母乳的早产儿提供母乳。捐赠者的筛选方法各不相同，和预期的供体通常通过行为筛查来筛查药物和娱乐物质的使用。尽管日本非法消费毒品的风险极低，咖啡因可能会在不知不觉中被消耗，并且可以在人乳中找到。迄今为止,关于供体牛奶中咖啡因的浓度只有少数报道。
这项研究旨在检查捐赠给日本一家牛奶银行的人乳中咖啡因的巴氏灭菌前水平。
■这是一个横截面，对捐赠给日本人乳银行的人乳中咖啡因浓度的观察性研究。使用高效液相色谱法测量供体乳中的咖啡因浓度。
■在70％的供体乳样品中检测到咖啡因（N=350）。咖啡因浓度的中位数（范围）为0.46[<0.10，7.54]mg/L，64.0%的样本中咖啡因含量低于1毫克/升。咖啡因浓度在个体之间以及个体内部变化很大。
■日本供体牛奶样品中的平均咖啡因浓度高于先前报道的西班牙样品中的咖啡因浓度，但范围相似。应告知捐赠者咖啡因摄入量应在中等范围内，进一步提高供体牛奶的安全性。
这项研究旨在检查捐赠给日本一家牛奶银行的人乳中咖啡因的巴氏灭菌前水平。
■这是一个横截面，对捐赠给日本人乳银行的人乳中咖啡因浓度的观察性研究。使用高效液相色谱法测量供体乳中的咖啡因浓度。
■在70％的供体乳样品中检测到咖啡因（N=350）。咖啡因浓度的中位数（范围）为0.46[<0.10，7.54]mg/L，64.0%的样本中咖啡因含量低于1毫克/升。咖啡因浓度在个体之间以及个体内部变化很大。
■日本供体牛奶样品中的平均咖啡因浓度高于先前报道的西班牙样品中的咖啡因浓度，但范围相似。应告知捐赠者咖啡因摄入量应在中等范围内，进一步提高供体牛奶的安全性。
