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Abstract：
UNASSIGNED: This study aimed to describe and compare the epidemiological, demographic, clinical, laboratory and radiological characteristics as well as the complications, treatments, and outcomes of these patients.
UNASSIGNED: We retrospectively investigated clinical data of patients with C. psittaci infection (psittacosis) in eight Grade IIIA hospitals of Fujian. Metagenomic next-generation sequencing (mNGS) was used identify C. psittaci in clinical samples of all included patients.
UNASSIGNED: A total of 74 patients (39 severe/35 non-severe) was diagnosed with psittacosis, 25 (33.8%) of whom had history of poultry exposure. Common symptoms included high fever (98% [37/74]), fatigue (52.7% [39/74]), and dyspnea (51.4% [38/74]). Common manifestations in imaging included consolidation (89.2%), pleural effusion (77.0%), and air bronchogram (66.2%). Common complications included acute respiratory distress syndrome (55.4% [41/74]), type I respiratory failure (52.7% [39/74]), acute liver injury (41.9% [31/74]), and secondary infection (27.0% [20/74]). The in-hospital mortality rate was 8.11% (6/74).
UNASSIGNED: C. psittaci infection is represents an underestimated cause of CAP. For SCAP patients with poultry and bird contact history, specimens were encouraged to be sended for mNGS test in time. C. psittaci infection can lead to severe, multiple system involvement, and several complications. mNGS facilitate timely diagnosis of C. psittaci infection.
UNASSIGNED: We retrospectively investigated clinical data of patients with C. psittaci infection (psittacosis) in eight Grade IIIA hospitals of Fujian. Metagenomic next-generation sequencing (mNGS) was used identify C. psittaci in clinical samples of all included patients.
UNASSIGNED: A total of 74 patients (39 severe/35 non-severe) was diagnosed with psittacosis, 25 (33.8%) of whom had history of poultry exposure. Common symptoms included high fever (98% [37/74]), fatigue (52.7% [39/74]), and dyspnea (51.4% [38/74]). Common manifestations in imaging included consolidation (89.2%), pleural effusion (77.0%), and air bronchogram (66.2%). Common complications included acute respiratory distress syndrome (55.4% [41/74]), type I respiratory failure (52.7% [39/74]), acute liver injury (41.9% [31/74]), and secondary infection (27.0% [20/74]). The in-hospital mortality rate was 8.11% (6/74).
UNASSIGNED: C. psittaci infection is represents an underestimated cause of CAP. For SCAP patients with poultry and bird contact history, specimens were encouraged to be sended for mNGS test in time. C. psittaci infection can lead to severe, multiple system involvement, and several complications. mNGS facilitate timely diagnosis of C. psittaci infection.
摘要：
■本研究旨在描述和比较流行病学，人口统计学,临床,实验室和放射学特征以及并发症，治疗,以及这些患者的结果。
■我们回顾性调查了福建8所三甲医院的鹦鹉感染（鹦鹉病）患者的临床资料。使用宏基因组下一代测序(mNGS)鉴定所有包括的患者的临床样品中的鹦鹉。
■共有74例患者（39例严重/35例非严重）被诊断为鹦鹉病，其中25人（33.8%）有家禽接触史。常见症状包括高烧（98%[37/74]），疲劳（52.7%[39/74]），和呼吸困难（51.4%[38/74]）。影像学的常见表现包括巩固（89.2％），胸腔积液（77.0%），和空气支气管图(66.2%)。常见的并发症包括急性呼吸窘迫综合征（55.4%[41/74]），I型呼吸衰竭(52.7%[39/74]),急性肝损伤（41.9%[31/74]），继发感染（27.0%[20/74]）。住院死亡率为8.11%(6/74)。
■C.鹦鹉螺感染是导致CAP被低估的原因。对于有家禽和鸟类接触史的SCAP患者，鼓励及时送检标本进行mNGS检测。C.鹦鹉感染可导致严重，多系统参与，和几个并发症。mNGS有助于鹦鹉感染的及时诊断。
■我们回顾性调查了福建8所三甲医院的鹦鹉感染（鹦鹉病）患者的临床资料。使用宏基因组下一代测序(mNGS)鉴定所有包括的患者的临床样品中的鹦鹉。
■共有74例患者（39例严重/35例非严重）被诊断为鹦鹉病，其中25人（33.8%）有家禽接触史。常见症状包括高烧（98%[37/74]），疲劳（52.7%[39/74]），和呼吸困难（51.4%[38/74]）。影像学的常见表现包括巩固（89.2％），胸腔积液（77.0%），和空气支气管图(66.2%)。常见的并发症包括急性呼吸窘迫综合征（55.4%[41/74]），I型呼吸衰竭(52.7%[39/74]),急性肝损伤（41.9%[31/74]），继发感染（27.0%[20/74]）。住院死亡率为8.11%(6/74)。
■C.鹦鹉螺感染是导致CAP被低估的原因。对于有家禽和鸟类接触史的SCAP患者，鼓励及时送检标本进行mNGS检测。C.鹦鹉感染可导致严重，多系统参与，和几个并发症。mNGS有助于鹦鹉感染的及时诊断。
