PDF(Pubmed)
Abstract：
BACKGROUND: Midday fogging is a complication of scleral lens (SL) wear that interrupts clear vision during the course of wear. SLs can be made with a variety of gas permeable materials, sizes and surface treatments, and various solutions are available for storing the lenses and for filling them before application on the eye. Many of these factors have been implicated as possible contributors to midday fogging. This study explored the lens and solution properties in habitual SL wearers with and without midday fogging.
METHODS: In this prospective study, 48 habitual SL wearers were evaluated and asked to report whether they experienced midday fogging and if they removed their lenses during the day. They completed the Ocular Surface Disease Index (OSDI), which is a validated tool for dry eye assessment. Lens parameters (material, coatings and diameter) and lens storage and filling solutions were documented. Backward elimination of regression terms evaluated the lens and solution properties in those with and without fogging. OSDI scores were compared using the Mann-Whitney analysis.
RESULTS: Collectively, the lens properties and solutions accounted for 27.7% of the variance related to midday fogging. None of the factors alone had a significant impact upon midday fogging. The median (interquartile range) OSDI score for those with fogging [37 (35)] was significantly different from those without fogging [10 (15)], with the scores corresponding to severe dry eye and normal eyes, respectively.
CONCLUSIONS: SL wearers with midday fogging exhibited similar symptoms to patients with severe dry eye. Lens and solution characteristics may play a small role in patients with midday fogging, although changing just a single factor is not likely to impact its presence.
METHODS: In this prospective study, 48 habitual SL wearers were evaluated and asked to report whether they experienced midday fogging and if they removed their lenses during the day. They completed the Ocular Surface Disease Index (OSDI), which is a validated tool for dry eye assessment. Lens parameters (material, coatings and diameter) and lens storage and filling solutions were documented. Backward elimination of regression terms evaluated the lens and solution properties in those with and without fogging. OSDI scores were compared using the Mann-Whitney analysis.
RESULTS: Collectively, the lens properties and solutions accounted for 27.7% of the variance related to midday fogging. None of the factors alone had a significant impact upon midday fogging. The median (interquartile range) OSDI score for those with fogging [37 (35)] was significantly different from those without fogging [10 (15)], with the scores corresponding to severe dry eye and normal eyes, respectively.
CONCLUSIONS: SL wearers with midday fogging exhibited similar symptoms to patients with severe dry eye. Lens and solution characteristics may play a small role in patients with midday fogging, although changing just a single factor is not likely to impact its presence.
摘要：
背景：中午起雾是巩膜镜片（SL）佩戴的并发症，在佩戴过程中会中断清晰的视力。SL可以用各种透气材料制成，尺寸和表面处理，和各种解决方案可用于存储镜片和用于在应用于眼睛之前填充它们。这些因素中的许多因素被认为是午间起雾的可能原因。这项研究探索了有和没有中午起雾的习惯性SL佩戴者的镜片和溶液特性。
方法：在这项前瞻性研究中，对48名习惯性SL佩戴者进行了评估，并要求他们报告是否经历了中午起雾以及他们是否在白天摘除了镜片。他们完成了眼表疾病指数（OSDI），这是干眼评估的有效工具。透镜参数(材料,涂层和直径）以及镜片储存和填充溶液均记录在案。回归项的向后消除评估了具有和不具有起雾的镜片和溶液性质。使用Mann-Whitney分析比较OSDI得分。
结果：总的来说，镜片特性和溶液占与午间起雾相关的方差的27.7%。没有一个因素单独对午间起雾有显著影响。有雾[37(35)]的OSDI评分中位数（四分位距）与没有雾[10(15)]的OSDI评分有显著差异，对应于严重干眼和正常眼睛的分数，分别。
结论：患有午间雾化的SL佩戴者表现出与重度干眼患者相似的症状。晶状体和溶液的特点可能在患者的午间起雾的作用小，尽管只改变一个因素不太可能影响它的存在。
方法：在这项前瞻性研究中，对48名习惯性SL佩戴者进行了评估，并要求他们报告是否经历了中午起雾以及他们是否在白天摘除了镜片。他们完成了眼表疾病指数（OSDI），这是干眼评估的有效工具。透镜参数(材料,涂层和直径）以及镜片储存和填充溶液均记录在案。回归项的向后消除评估了具有和不具有起雾的镜片和溶液性质。使用Mann-Whitney分析比较OSDI得分。
结果：总的来说，镜片特性和溶液占与午间起雾相关的方差的27.7%。没有一个因素单独对午间起雾有显著影响。有雾[37(35)]的OSDI评分中位数（四分位距）与没有雾[10(15)]的OSDI评分有显著差异，对应于严重干眼和正常眼睛的分数，分别。
结论：患有午间雾化的SL佩戴者表现出与重度干眼患者相似的症状。晶状体和溶液的特点可能在患者的午间起雾的作用小，尽管只改变一个因素不太可能影响它的存在。
