Abstract：
Diabetes mellitus(DM) is a chronic endocrine disease characterized by hyperglycemia caused by carbohydrate or lipid metabolism disorders or insulin dysfunction. Hyperglycemia and long-term metabolic disorders in DM can damage tissues and organs throughout the body, leading to serious complications. Mitochondrial autophagy(mitophagy) is an important mitochondrial quality control process in cells and a special autophagy phenomenon, in which damaged or redundant mitochondria can be selectively removed by autophagic lysosome, which is crucial to maintain cell stability and survival under stress. Studies have confirmed that changes in autophagy play a role in the development and control of DM and its complications. Mitophagy has become a research hotspot in recent years and it is closely associated with the pathogenesis of a variety of diseases. Substantial evidence suggests that mitophagy plays a crucial role in regulating the metabolic homeostasis in the case of DM and its complications. Because the destructive great vessel complications and microvascular complications cause increased mortality, blindness, renal failure, and declined quality of life of DM patients, it is urgent to develop targeted therapies to intervene in DM and its complications. Traditional Chinese medicine(TCM), with a multi-component, multi-target, and multi-level action manner, can prevent the development of drug resistance and have significant therapeutic effects in the prevention and treatment of DM and its complications. Therefore, exploring the mechanisms of TCM in regulating mito-phagy may become a new method for treating DM and its complications. With focus on the roles and mechanisms of mitophagy in DM and its complications, this paper summarizes and prospects the research on the treatment of DM and its complications with TCM via re-gulating mitophagy, aiming to provide new ideas for the clinical practice.
摘要：
糖尿病（DM）是一种慢性内分泌疾病，其特征是由碳水化合物或脂质代谢紊乱或胰岛素功能障碍引起的高血糖。糖尿病患者的高血糖和长期代谢紊乱可损害全身组织和器官，导致严重的并发症。线粒体自噬(mitophagy)是细胞内重要的线粒体质量控制过程,是一种特殊的自噬现象,其中受损或多余的线粒体可以通过自噬溶酶体选择性去除，这对于维持细胞的稳定性和在压力下的存活至关重要。研究证实自噬的改变在DM及其并发症的发生发展和控制中发挥作用。线粒体自噬已成为近年来的研究热点,与多种疾病的发病机制密切相关。大量证据表明，在DM及其并发症的情况下，线粒体自噬在调节代谢稳态中起着至关重要的作用。因为破坏性的大血管并发症和微血管并发症导致死亡率增加，失明,肾功能衰竭,糖尿病患者的生活质量下降，迫切需要开发靶向治疗来干预DM及其并发症。中药(TCM),有了多组分，多目标,多层次的行动方式，能预防耐药性的发展,对DM及其并发症的防治有显著的治疗作用。因此,探索中医调控mito-phagy的机制可能成为治疗DM及其并发症的新方法。重点探讨线粒体自噬在DM及其并发症中的作用和机制,本文对中医药通过调节线粒体自噬治疗糖尿病及其并发症的研究进行了总结和展望,旨在为临床实践提供新思路。
