PDF(Pubmed)
Abstract：
Anemia and acute heart failure (AHF) frequently coexist. Several published studies have investigated the association of anemia with all-cause mortality and all-cause heart failure events in AHF patients, but their findings remain controversial. This study is intended to evaluate the relationship between anemia and AHF. We systematically searched PubMed, Medline, the Cochrane Library, Embase, and Elsevier\'s ScienceDirect databases until July 30, 2023, and selected prospective or retrospective cohort studies to evaluate anemia for AHF. A total of nine trials involving 29 587 AHF patients were eventually included. Pooled analyses demonstrated anemia is associated with a higher risk of all-cause heart failure event rate (OR: 1.82, 95% CI: 1.58-2.10, p < .01) and all-cause mortality, both for short-term (30 days) all-cause mortality (OR: 1.91, 95% CI: 1.31-2.79, p < .01) and long-term (1 year) all-cause mortality (OR: 1.72, 95% CI: 1.27-2.32, p < .01). The evidence from this meta-analysis suggested that anemia may be an independent risk factor for all-cause mortality and all-cause heart failure events in patients with AHF and might emphasize the importance of anemia correction before discharge.
摘要：
贫血和急性心力衰竭（AHF）经常共存。一些已发表的研究调查了AHF患者贫血与全因死亡率和全因心力衰竭事件的关系。但是他们的发现仍然存在争议。本研究旨在评估贫血与AHF之间的关系。我们系统地搜索了PubMed,Medline,Cochrane图书馆,Embase,和Elsevier的ScienceDirect数据库，直到2023年7月30日，并选择了前瞻性或回顾性队列研究来评估AHF的贫血。最终纳入了总共9项试验，涉及29587名AHF患者。汇总分析表明，贫血与全因心力衰竭事件发生率（OR：1.82，95％CI：1.58-2.10，p<0.01）和全因死亡率相关，短期（30天）全因死亡率（OR：1.91，95%CI：1.31-2.79，p<.01）和长期（1年）全因死亡率（OR：1.72，95%CI：1.27-2.32，p<.01）。这项荟萃分析的证据表明，贫血可能是AHF患者全因死亡和全因心力衰竭事件的独立危险因素，并可能强调出院前纠正贫血的重要性。
