PDF(Pubmed)
Abstract：
OBJECTIVE: To evaluate the Schlemm\'s canal (SC) parameters obtained by swept-source optical coherence tomography (OCT) different in Graves\' ophthalmopathy (GO) eyes compared to healthy eyes.
METHODS: This cross-sectional observational study evaluated 64 eyes of 32 GO cases and 56 eyes of 28 healthy controls. The study was conducted between October 2020 and June 2021. SC images were obtained from the temporal limbus of individuals using swept-source OCT. SC length (SCL) and SC area (SCA) were measured. The relationship between SC parameters in the patient group and intraocular pressure (IOP), retinal nerve fiber layer (RNFL) thickness, Graves\' disease (GD) duration, and clinical activity score (CAS) was evaluated.
RESULTS: In the GO group, 64 eyes of 32 patients were evaluated, and in the age and gender-matched healthy control group, 56 eyes of 28 individuals were assessed. SC images from 4 eyes of 4 patients in the patient group and 1 eye of 1 patient in the control group were not clear, preventing SCL and SCA measurements for these eyes. SCL and SCA measurements were found to be lower, and IOP and Hertel values were higher in the GO group compared to the healthy controls. However, no significant correlation was observed between SCL and SCA with IOP, RNFL thickness, GD duration, GO duration, or CAS in the GO group. In the GO group, the mean value of SCA was found to be higher in eyes with glaucoma or OHT compared to those without.
CONCLUSIONS: These findings indicate that SC in GO-affected eyes is shorter and has a smaller area than in healthy individuals. Additionally, higher IOP and Hertel values were observed in the GO group compared to healthy controls. This study suggests that assessing SC using anterior segment OCT could provide valuable insights into the regulation of IOP and the development of glaucoma in GO-affected eyes.
METHODS: This cross-sectional observational study evaluated 64 eyes of 32 GO cases and 56 eyes of 28 healthy controls. The study was conducted between October 2020 and June 2021. SC images were obtained from the temporal limbus of individuals using swept-source OCT. SC length (SCL) and SC area (SCA) were measured. The relationship between SC parameters in the patient group and intraocular pressure (IOP), retinal nerve fiber layer (RNFL) thickness, Graves\' disease (GD) duration, and clinical activity score (CAS) was evaluated.
RESULTS: In the GO group, 64 eyes of 32 patients were evaluated, and in the age and gender-matched healthy control group, 56 eyes of 28 individuals were assessed. SC images from 4 eyes of 4 patients in the patient group and 1 eye of 1 patient in the control group were not clear, preventing SCL and SCA measurements for these eyes. SCL and SCA measurements were found to be lower, and IOP and Hertel values were higher in the GO group compared to the healthy controls. However, no significant correlation was observed between SCL and SCA with IOP, RNFL thickness, GD duration, GO duration, or CAS in the GO group. In the GO group, the mean value of SCA was found to be higher in eyes with glaucoma or OHT compared to those without.
CONCLUSIONS: These findings indicate that SC in GO-affected eyes is shorter and has a smaller area than in healthy individuals. Additionally, higher IOP and Hertel values were observed in the GO group compared to healthy controls. This study suggests that assessing SC using anterior segment OCT could provide valuable insights into the regulation of IOP and the development of glaucoma in GO-affected eyes.
摘要：
目的：评估通过扫频光学相干断层扫描（OCT）获得的Graves眼病（GO）眼与健康眼相比不同的Schlemm管（SC）参数。
方法：这项横断面观察研究评估了32例GO患者的64只眼和28例健康对照者的56只眼。这项研究是在2020年10月至2021年6月之间进行的。使用扫频源OCT从个体的颞缘获得SC图像。测量SC长度(SCL)和SC面积(SCA)。患者组的SC参数与眼压（IOP）之间的关系，视网膜神经纤维层（RNFL）厚度，严重疾病（GD）持续时间，并对临床活动评分(CAS)进行评估。
结果：在GO组中，对32例患者的64只眼进行了评估，在年龄和性别匹配的健康对照组中，对28人的56只眼进行了评估。患者组4例患者的4只眼和对照组1例患者的1只眼的SC图像不清楚，防止这些眼睛的SCL和SCA测量。SCL和SCA测量结果较低，与健康对照组相比，GO组的IOP和Hertel值更高。然而,SCL和SCA与IOP之间无显著相关性，RNFL厚度,GD持续时间,GO持续时间,或GO组中的CAS。在GO组中，与无青光眼或OHT的患者相比,有青光眼或OHT的患者的SCA平均值更高.
结论：这些发现表明，受GO影响的眼睛中的SC比健康个体更短，面积更小。此外,与健康对照组相比,GO组的IOP和Hertel值较高.这项研究表明，使用眼前节OCT评估SC可以为受GO影响的眼睛中IOP的调节和青光眼的发展提供有价值的见解。
方法：这项横断面观察研究评估了32例GO患者的64只眼和28例健康对照者的56只眼。这项研究是在2020年10月至2021年6月之间进行的。使用扫频源OCT从个体的颞缘获得SC图像。测量SC长度(SCL)和SC面积(SCA)。患者组的SC参数与眼压（IOP）之间的关系，视网膜神经纤维层（RNFL）厚度，严重疾病（GD）持续时间，并对临床活动评分(CAS)进行评估。
结果：在GO组中，对32例患者的64只眼进行了评估，在年龄和性别匹配的健康对照组中，对28人的56只眼进行了评估。患者组4例患者的4只眼和对照组1例患者的1只眼的SC图像不清楚，防止这些眼睛的SCL和SCA测量。SCL和SCA测量结果较低，与健康对照组相比，GO组的IOP和Hertel值更高。然而,SCL和SCA与IOP之间无显著相关性，RNFL厚度,GD持续时间,GO持续时间,或GO组中的CAS。在GO组中，与无青光眼或OHT的患者相比,有青光眼或OHT的患者的SCA平均值更高.
结论：这些发现表明，受GO影响的眼睛中的SC比健康个体更短，面积更小。此外,与健康对照组相比,GO组的IOP和Hertel值较高.这项研究表明，使用眼前节OCT评估SC可以为受GO影响的眼睛中IOP的调节和青光眼的发展提供有价值的见解。
