PDF(Pubmed)
Abstract：
Over the last three years, the pandemic of COVID-19 has had a significant impact on people\'s lives and the global economy. The incessant emergence of variant strains has compounded the challenges associated with the management of COVID-19. As the predominant variant from late 2021 to the present, Omicron and its sublineages, through continuous evolution, have demonstrated iterative viral fitness. The comprehensive elucidation of the biological implications that catalyzed this evolution remains incomplete. In accordance with extant research evidence, we provide a comprehensive review of subvariants of Omicron, delineating alterations in immune evasion, cellular infectivity, and the cross-species transmission potential. This review seeks to clarify the underpinnings of biology within the evolution of SARS-CoV-2, thereby providing a foundation for strategic considerations in the post-pandemic era of COVID-19.
摘要：
在过去的三年里，COVID-19的流行对人们的生活和全球经济产生了重大影响。变异株的不断出现加剧了与COVID-19管理相关的挑战。作为从2021年底到现在的主要变体，Omicron及其子谱系，通过不断的进化，已经证明了病毒的迭代适应性。对催化这种进化的生物学意义的全面阐明仍然不完整。根据现有的研究证据，我们提供了对Omicron亚变体的全面审查，描绘免疫逃避的改变，细胞感染性，以及跨物种传播的潜力。这篇评论旨在阐明SARS-CoV-2进化过程中生物学的基础，从而为COVID-19大流行后时代的战略考虑奠定基础。
