Abstract：
UNASSIGNED: Research on nanotechnology in medicine has also involved the ocular field and nanomicelles are among the applications developed. This approach is used to increase both the water solubility of hydrophobic drugs and their penetration/permeation within/through the ocular tissues since nanomicelles are able to encapsulate insoluble drug into their core and their small size allows them to penetrate and/or diffuse through the aqueous pores of ocular tissues.
UNASSIGNED: The present review reports the most significant and recent literature on the use of nanomicelles, made up of both surfactants and amphiphilic polymers, to overcome limitations imposed by the physiology of the eye in achieving a high bioavailability of drugs intended for the therapeutic areas of greatest commercial interest: dry eye, inflammation, and glaucoma.
UNASSIGNED: The results of the numerous studies in this field are encouraging and demonstrate that nanomicelles may be the answer to some of the challenges of ocular therapy. In the future, new molecules self-assembling into micelles will be able to meet the regulatory requirements for marketing authorization for their use in ophthalmic formulations.
UNASSIGNED: The present review reports the most significant and recent literature on the use of nanomicelles, made up of both surfactants and amphiphilic polymers, to overcome limitations imposed by the physiology of the eye in achieving a high bioavailability of drugs intended for the therapeutic areas of greatest commercial interest: dry eye, inflammation, and glaucoma.
UNASSIGNED: The results of the numerous studies in this field are encouraging and demonstrate that nanomicelles may be the answer to some of the challenges of ocular therapy. In the future, new molecules self-assembling into micelles will be able to meet the regulatory requirements for marketing authorization for their use in ophthalmic formulations.
摘要：
■纳米技术在医学中的研究也涉及眼部领域，纳米胶束是开发的应用之一。该方法用于增加疏水性药物的水溶性和它们在眼组织内/通过眼组织的渗透/渗透,因为纳米胶束能够将不溶性药物包封到它们的核心中,并且它们的小尺寸允许它们穿透和/或扩散通过眼组织的水性孔。
■本综述报告了有关纳米胶束使用的最重要和最新文献，由表面活性剂和两亲性聚合物组成，为了克服眼睛生理学在实现用于最大商业利益的治疗领域的药物的高生物利用度方面施加的限制：干眼，炎症,和青光眼。
■该领域的大量研究结果令人鼓舞，并证明纳米胶束可能是解决眼部治疗的一些挑战的答案。将来，自组装成胶束的新分子将能够满足其在眼用制剂中使用的上市许可的监管要求。
■本综述报告了有关纳米胶束使用的最重要和最新文献，由表面活性剂和两亲性聚合物组成，为了克服眼睛生理学在实现用于最大商业利益的治疗领域的药物的高生物利用度方面施加的限制：干眼，炎症,和青光眼。
■该领域的大量研究结果令人鼓舞，并证明纳米胶束可能是解决眼部治疗的一些挑战的答案。将来，自组装成胶束的新分子将能够满足其在眼用制剂中使用的上市许可的监管要求。
