UNASSIGNED: The present review reports the most significant and recent literature on the use of nanomicelles, made up of both surfactants and amphiphilic polymers, to overcome limitations imposed by the physiology of the eye in achieving a high bioavailability of drugs intended for the therapeutic areas of greatest commercial interest: dry eye, inflammation, and glaucoma.
UNASSIGNED: The results of the numerous studies in this field are encouraging and demonstrate that nanomicelles may be the answer to some of the challenges of ocular therapy. In the future, new molecules self-assembling into micelles will be able to meet the regulatory requirements for marketing authorization for their use in ophthalmic formulations.
■本综述报告了有关纳米胶束使用的最重要和最新文献,由表面活性剂和两亲性聚合物组成,为了克服眼睛生理学在实现用于最大商业利益的治疗领域的药物的高生物利用度方面施加的限制:干眼,炎症,和青光眼。
■该领域的大量研究结果令人鼓舞,并证明纳米胶束可能是解决眼部治疗的一些挑战的答案。将来,自组装成胶束的新分子将能够满足其在眼用制剂中使用的上市许可的监管要求。