Abstract：
Infant and toddler food (ITF), including powdered infant and follow-up formula (PIFF) and complementary food (CF), provides the majority of early-life nutrients for young children. As infants and toddlers are more vulnerable to foodborne diseases, the safety concern of ITF is the ultimate priority. However, nationwide surveillance for the presence of hazards, specifically microbiological hazards, in the Chinese ITF is partially known, posing a significant knowledge gap for risk ranking. Most importantly, the related regional surveys were largely published in Chinese, making the data unavailable for global sharing. To bridge these gaps, we screened 5,306 publications and conducted a comprehensive meta-analysis for microbiological hazards using 129 qualified studies. The four most reported microbiological hazards in ITF were Bacillus cereus (13.4 %), Cronobacter (4.8 %), Staphylococcus aureus (1.3 %), and Salmonella (1.1 %). B. cereus is a risk factor in ITF, specifically in PIFF, cereals, and ready-to-eat food. The prevalence of B. cereus was high in Northern and Southern China, while the prevalence of Cronobacter was high in Central China. Cronobacter is a microbiological hazard, specifically in PIFF, with a prevalence of 3.0 %. Interestingly, the prevalence dynamics of Cronobacter and B. cereus in ITF were rising and stable, respectively, whereas the prevalence of S. aureus and Salmonella decreased over time. Together, our analysis will promote the global sharing of these critical findings and may guide future policy making.
摘要：
婴幼儿食品（ITF）包括婴儿和后续配方奶粉(PIFF)和辅食(CF)，为幼儿提供大部分的早期营养。由于婴儿和幼儿更容易受到食源性疾病的影响，ITF的安全问题是最终的优先事项。然而,在全国范围内监测危险的存在，特别是微生物危害，在中国ITF是部分已知的，为风险排名带来了巨大的知识差距。最重要的是,相关的区域调查大部分是用中文发表的，使数据不可用于全球共享。为了弥合这些差距，我们筛选了5,306份出版物,并使用129项合格研究对微生物危害进行了全面的荟萃分析.ITF中报道最多的四种微生物危害是蜡状芽孢杆菌（13.4%），Cronobacter(4.8%),金黄色葡萄球菌（1.3%），和沙门氏菌(1.1%)。B.蜡质是ITF中的一个风险因素，特别是在PIFF中，谷物,和即食食品。蜡状芽孢杆菌在中国北方和南方的患病率很高，而在华中地区，Cronobacter的患病率很高。Cronobacter是一种微生物危害，特别是在PIFF中，患病率为3.0%。有趣的是,Cronobacter和蜡样芽孢杆菌在ITF中的流行动态呈上升和稳定，分别,而金黄色葡萄球菌和沙门氏菌的患病率随着时间的推移而下降。一起,我们的分析将促进全球分享这些重要发现，并可能指导未来的政策制定。
