亨廷顿病转基因绵羊模型的体细胞 CAG 重复稳定性。
关键词: CAG repeat Huntington’s disease OVT73 animal model genetic modifier somatic instability transgenic sheep
Mesh : Animals Sheep / genetics Humans Child Child, Preschool Huntington Disease / metabolism Corpus Striatum / metabolism Neostriatum / metabolism Mutation Age of Onset Huntingtin Protein / genetics metabolism Trinucleotide Repeat Expansion / genetics Disease Models, Animal
来 源:
DOI:10.3233/JHD-231516
PDF(Pubmed)