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Abstract：
The main purpose of this study is to explore the outcomes of patients found to have gallbladder cancer during investigation and diagnosis of acute cholecystitis. The incidence of primary gallbladder cancer co-existing in acute cholecystitis is not well defined in the literature, with anecdotal reports suggesting that they experience worse outcomes than patients with gallbladder cancer found incidentally.
METHODS: A retrospective review of all patients with gallbladder cancer managed at the Canberra Health Service between 1998 and May 2022 were identified and reviewed.
RESULTS: A total of 65 patients were diagnosed with primary gallbladder cancer during the study period with a mean age of 70.4 years (SD 11.4, range 59-81.8 years) and a female preponderance (74% versus 26%) with a ratio of 2.8. Twenty (31%) patients presented with acute calculus cholecystitis and were found to have a primary gallbladder cancer. This group of patients were older and predominantly female, but the difference was not statistically significant. The overall 5-year survival in the cohort was 20% (stage 1 63%, stage 2 23%, stage 3 16%, and stage 4 0%). There was no statistically significant difference in survival between those who presented with acute cholecystitis vs other presentations.
CONCLUSIONS: A third of the patients with gallbladder cancer presented with acute cholecystitis. There was no statistically significant difference in survival in those with bile spillage during cholecystectomy as well those presenting with acute cholecystitis.
METHODS: A retrospective review of all patients with gallbladder cancer managed at the Canberra Health Service between 1998 and May 2022 were identified and reviewed.
RESULTS: A total of 65 patients were diagnosed with primary gallbladder cancer during the study period with a mean age of 70.4 years (SD 11.4, range 59-81.8 years) and a female preponderance (74% versus 26%) with a ratio of 2.8. Twenty (31%) patients presented with acute calculus cholecystitis and were found to have a primary gallbladder cancer. This group of patients were older and predominantly female, but the difference was not statistically significant. The overall 5-year survival in the cohort was 20% (stage 1 63%, stage 2 23%, stage 3 16%, and stage 4 0%). There was no statistically significant difference in survival between those who presented with acute cholecystitis vs other presentations.
CONCLUSIONS: A third of the patients with gallbladder cancer presented with acute cholecystitis. There was no statistically significant difference in survival in those with bile spillage during cholecystectomy as well those presenting with acute cholecystitis.
摘要：
这项研究的主要目的是探讨在急性胆囊炎的调查和诊断过程中发现胆囊癌的患者的预后。原发性胆囊癌在急性胆囊炎中的发病率在文献中没有很好的定义。轶事报告表明，他们的预后比偶然发现的胆囊癌患者差。
方法：对1998年至2022年5月在堪培拉卫生服务局治疗的所有胆囊癌患者进行了回顾性审查。
结果：在研究期间，共有65例患者被诊断为原发性胆囊癌，平均年龄为70.4岁（SD11.4，范围59-81.8岁），女性优势（74％对26％），比例为2.8。20例（31％）患者出现急性结石性胆囊炎，并被发现患有原发性胆囊癌。这组患者年龄较大，以女性为主，但差异无统计学意义。该队列的5年总生存率为20％（1期63％，第二阶段23%，阶段316%，和阶段40%)。急性胆囊炎患者与其他患者之间的生存率没有统计学上的显着差异。
结论：1/3的胆囊癌患者表现为急性胆囊炎。胆囊切除术中胆汁溢出的患者以及急性胆囊炎患者的生存率没有统计学上的显着差异。
方法：对1998年至2022年5月在堪培拉卫生服务局治疗的所有胆囊癌患者进行了回顾性审查。
结果：在研究期间，共有65例患者被诊断为原发性胆囊癌，平均年龄为70.4岁（SD11.4，范围59-81.8岁），女性优势（74％对26％），比例为2.8。20例（31％）患者出现急性结石性胆囊炎，并被发现患有原发性胆囊癌。这组患者年龄较大，以女性为主，但差异无统计学意义。该队列的5年总生存率为20％（1期63％，第二阶段23%，阶段316%，和阶段40%)。急性胆囊炎患者与其他患者之间的生存率没有统计学上的显着差异。
结论：1/3的胆囊癌患者表现为急性胆囊炎。胆囊切除术中胆汁溢出的患者以及急性胆囊炎患者的生存率没有统计学上的显着差异。
