PDF(Pubmed)
Abstract：
Chronic wasting disease (CWD) is a prion disease affecting cervid species, both free-ranging and captive populations. As the geographic range continues to expand and disease prevalence continues to increase, CWD will have an impact on cervid populations, local economies, and ecosystem health. Mitigation of this \"wicked\" disease will require input from many different stakeholders including hunters, landowners, research biologists, wildlife managers, and others, working together. The NC1209 (North American interdisciplinary chronic wasting disease research consortium) is composed of scientists from different disciplines involved with investigating and managing CWD. Leveraging this broad breadth of expertise, the Consortium has created a state-of-the-science review of five key aspects of CWD, including current diagnostic capabilities for detecting prions, requirements for validating these diagnostics, the role of environmental transmission in CWD dynamics, and potential zoonotic risks associated with CWD. The goal of this review is to increase stakeholders\', managers\', and decision-makers\' understanding of this disease informed by current scientific knowledge.
摘要：
慢性消耗性疾病（CWD）是一种影响子宫颈物种的朊病毒疾病，自由放养和圈养人口。随着地理范围的不断扩大和疾病患病率的不断增加，CWD将对宫颈种群产生影响，地方经济,和生态系统健康。缓解这种“邪恶”疾病需要包括猎人在内的许多不同利益相关者的投入，地主,研究生物学家，野生动物管理者,和其他人,一起工作。NC1209（北美跨学科慢性消耗性疾病研究联盟）由来自不同学科的科学家组成，涉及调查和管理CWD。利用这种广泛的专业知识，财团对CWD的五个关键方面进行了科学审查，包括目前检测朊病毒的诊断能力，验证这些诊断的要求，环境传输在CWD动力学中的作用，以及与CWD相关的潜在人畜共患病风险。本次审查的目标是增加利益相关者，经理\'，和决策者对这种疾病的理解取决于当前的科学知识。
