Abstract：
OBJECTIVE: This systematic review aims to analyze the existing literature investigating respiratory functioning in people with Persistent Somatic Symptoms (PSS) compared to healthy controls, to identify patterns of respiratory disturbances by symptom or syndrome, and describe any respiratory outcomes consistent across diagnoses.
METHODS: A systematic review following PRISMA guidelines was conducted. A comprehensive search was carried out across five databases (PubMed (NCBI), PsycArticles (Ovid), Web of Science (Core Collection), Embase, and Scopus) using two customised search strings for persistent somatic symptoms and objective respiratory parameters. Title/abstract screening and data extraction were carried out independently by two reviewers. The modified Newcastle-Ottawa Scale was used for quality assessment of the studies. Studies investigating baseline respiratory functioning in adult patients with PSS compared to healthy controls, using at least one objective respiratory were included.
RESULTS: 18 studies met the inclusion criteria for the review, with a pooled sample size of n = 3245. Chronic pain conditions were found to be the most prevalent subset of diagnoses of interest, comprising six of the studies. 10 studies included measures of lung capacity, flow and/or volume, nine studies reported measures of ventilation, and four studies investigated respiratory muscle functioning. 13 of the included studies reported significant differences in at least one objective respiratory measure between groups (at rest). Scores on self-reported measures of dysnpea and breathlessness were higher in patients compared to healthy controls, while objective respiratory outcomes were varied.
CONCLUSIONS: The current systematic review is consistent with previous literature suggesting more pronounced experiences of breathlessness in patients with PSS, and significant disparities between reported dyspnea and objective respiratory outcomes. Research investigating the uncoupling between subjective and objective respiratory outcomes is needed to understand the mechanisms behind breathing disturbances in PSS.
METHODS: A systematic review following PRISMA guidelines was conducted. A comprehensive search was carried out across five databases (PubMed (NCBI), PsycArticles (Ovid), Web of Science (Core Collection), Embase, and Scopus) using two customised search strings for persistent somatic symptoms and objective respiratory parameters. Title/abstract screening and data extraction were carried out independently by two reviewers. The modified Newcastle-Ottawa Scale was used for quality assessment of the studies. Studies investigating baseline respiratory functioning in adult patients with PSS compared to healthy controls, using at least one objective respiratory were included.
RESULTS: 18 studies met the inclusion criteria for the review, with a pooled sample size of n = 3245. Chronic pain conditions were found to be the most prevalent subset of diagnoses of interest, comprising six of the studies. 10 studies included measures of lung capacity, flow and/or volume, nine studies reported measures of ventilation, and four studies investigated respiratory muscle functioning. 13 of the included studies reported significant differences in at least one objective respiratory measure between groups (at rest). Scores on self-reported measures of dysnpea and breathlessness were higher in patients compared to healthy controls, while objective respiratory outcomes were varied.
CONCLUSIONS: The current systematic review is consistent with previous literature suggesting more pronounced experiences of breathlessness in patients with PSS, and significant disparities between reported dyspnea and objective respiratory outcomes. Research investigating the uncoupling between subjective and objective respiratory outcomes is needed to understand the mechanisms behind breathing disturbances in PSS.
摘要：
目的：本系统综述旨在分析现有文献，研究持续性躯体症状（PSS）患者与健康对照组的呼吸功能，通过症状或综合征来识别呼吸紊乱的模式，并描述所有诊断结果一致的呼吸结果。
方法：按照PRISMA指南进行系统评价。在五个数据库(PubMed(NCBI)，Psycarticles(Ovid),WebofScience(核心合集),Embase,和Scopus）使用两个自定义的搜索字符串来查找持续的躯体症状和客观的呼吸参数。标题/摘要筛选和数据提取由两名审稿人独立进行。改良的纽卡斯尔-渥太华量表用于研究的质量评估。研究调查与健康对照组相比，PSS成年患者的基线呼吸功能，包括使用至少一个客观呼吸。
结果：18项研究符合纳入标准，合并样本量为n=3245。慢性疼痛病症被发现是最普遍的感兴趣的诊断子集，包括六项研究。10项研究包括肺活量的测量，流量和/或体积，九项研究报告了通风措施，四项研究调查了呼吸肌功能。纳入的研究中有13项报道了组间(休息时)至少一项客观呼吸测量的显著差异。与健康对照组相比，患者自我报告的呼吸困难和呼吸困难的得分更高，而客观的呼吸结局各不相同。
结论：当前的系统评价与以前的文献一致，这些文献表明PSS患者呼吸困难的经历更为明显，以及报告的呼吸困难和客观呼吸结局之间的显著差异。需要研究主观和客观呼吸结果之间的解耦，以了解PSS中呼吸障碍背后的机制。
方法：按照PRISMA指南进行系统评价。在五个数据库(PubMed(NCBI)，Psycarticles(Ovid),WebofScience(核心合集),Embase,和Scopus）使用两个自定义的搜索字符串来查找持续的躯体症状和客观的呼吸参数。标题/摘要筛选和数据提取由两名审稿人独立进行。改良的纽卡斯尔-渥太华量表用于研究的质量评估。研究调查与健康对照组相比，PSS成年患者的基线呼吸功能，包括使用至少一个客观呼吸。
结果：18项研究符合纳入标准，合并样本量为n=3245。慢性疼痛病症被发现是最普遍的感兴趣的诊断子集，包括六项研究。10项研究包括肺活量的测量，流量和/或体积，九项研究报告了通风措施，四项研究调查了呼吸肌功能。纳入的研究中有13项报道了组间(休息时)至少一项客观呼吸测量的显著差异。与健康对照组相比，患者自我报告的呼吸困难和呼吸困难的得分更高，而客观的呼吸结局各不相同。
结论：当前的系统评价与以前的文献一致，这些文献表明PSS患者呼吸困难的经历更为明显，以及报告的呼吸困难和客观呼吸结局之间的显著差异。需要研究主观和客观呼吸结果之间的解耦，以了解PSS中呼吸障碍背后的机制。
