PDF(Pubmed)
Abstract：
UNASSIGNED: The aim of this retrospective study was to explore the diagnostic potential of various cardiac parameters in differentiating between heart failure with preserved ejection fraction (HFpEF) and heart failure with mid-ranged and reduced ejection fraction (HFm + rEF), and to discern their relationship with normal cardiac function.
UNASSIGNED: This research encompassed a comparative analysis of heart failure subtypes based on multiple indicators. Participants were categorized into HFm + rEF, HFpEF, and control groups. For each participant, we investigated indicators of left ventricular function (LVEDVi, LVESVi, and LVEF) and myocardial strain parameters (GLS, GCS, GRS). Additionally, quantitative tissue evaluation parameters including native T1, enhanced T1, and extracellular volume (ECV) were examined.For comprehensive diagnostic performance analysis, receiver operating characteristic (ROC) curve evaluations for each parameters were conducted.
UNASSIGNED: HFm + rEF patients exhibited elevated LVEDVi and LVESVi and decreased LVEF compared to both HFpEF and control groups. Myocardial strain revealed significant reductions in GLS, GCS, and GRS for HFm + rEF patients compared to the other groups. HFpEF patients showed strain reductions relative to the control group. In cardiac magnetic resonance imaging (CMR) evaluations, HFm + rEF patients demonstrated heightened native T1 times and ECV fractions. Native T1 was particularly effective in distinguishing HFpEF from healthy subjects.
UNASSIGNED: Native T1, ECV, and myocardial strain parameters have substantial diagnostic value in identifying HFpEF. Among them, native T1 displayed superior diagnostic efficiency relative to ECV, offering critical insights into early-stage HFpEF. These findings can play a pivotal role in refining clinical management and treatment strategies for heart failure patients.
UNASSIGNED: This research encompassed a comparative analysis of heart failure subtypes based on multiple indicators. Participants were categorized into HFm + rEF, HFpEF, and control groups. For each participant, we investigated indicators of left ventricular function (LVEDVi, LVESVi, and LVEF) and myocardial strain parameters (GLS, GCS, GRS). Additionally, quantitative tissue evaluation parameters including native T1, enhanced T1, and extracellular volume (ECV) were examined.For comprehensive diagnostic performance analysis, receiver operating characteristic (ROC) curve evaluations for each parameters were conducted.
UNASSIGNED: HFm + rEF patients exhibited elevated LVEDVi and LVESVi and decreased LVEF compared to both HFpEF and control groups. Myocardial strain revealed significant reductions in GLS, GCS, and GRS for HFm + rEF patients compared to the other groups. HFpEF patients showed strain reductions relative to the control group. In cardiac magnetic resonance imaging (CMR) evaluations, HFm + rEF patients demonstrated heightened native T1 times and ECV fractions. Native T1 was particularly effective in distinguishing HFpEF from healthy subjects.
UNASSIGNED: Native T1, ECV, and myocardial strain parameters have substantial diagnostic value in identifying HFpEF. Among them, native T1 displayed superior diagnostic efficiency relative to ECV, offering critical insights into early-stage HFpEF. These findings can play a pivotal role in refining clinical management and treatment strategies for heart failure patients.
摘要：
■这项回顾性研究的目的是探索各种心脏参数在区分射血分数保留的心力衰竭（HFpEF）和射血分数降低的心力衰竭（HFmrEF）之间的诊断潜力。并辨别它们与正常心功能的关系。
■这项研究涵盖了基于多个指标的心力衰竭亚型的比较分析。参与者被分为HFm+rEF，HFpEF,和对照组。对于每个参与者，我们调查了左心室功能的指标(LVEDVi，LVESVi,和LVEF)和心肌应变参数(GLS，GCS,GRS).此外,检查了定量组织评估参数，包括天然T1，增强T1和细胞外体积（ECV）。对于全面的诊断性能分析，对各参数进行受试者工作特征(ROC)曲线评价。
■与HFpEF和对照组相比，HFm+rEF患者的LVEDVi和LVESVi升高，LVEF降低。心肌劳损显示GLS显著降低，GCS,与其他组相比，HFm+rEF患者的GRS。HFpEF患者相对于对照组显示应变减少。在心脏磁共振成像（CMR）评估中，HFmrEF患者表现出升高的天然T1时间和ECV分数。天然T1在区分HFpEF与健康受试者方面特别有效。
■本机T1、ECV、和心肌应变参数在鉴定HFpEF方面具有重要的诊断价值。其中,相对于ECV，原生T1显示出较高的诊断效率，提供对早期HFpEF的关键见解。这些发现可以在完善心力衰竭患者的临床管理和治疗策略中发挥关键作用。
■这项研究涵盖了基于多个指标的心力衰竭亚型的比较分析。参与者被分为HFm+rEF，HFpEF,和对照组。对于每个参与者，我们调查了左心室功能的指标(LVEDVi，LVESVi,和LVEF)和心肌应变参数(GLS，GCS,GRS).此外,检查了定量组织评估参数，包括天然T1，增强T1和细胞外体积（ECV）。对于全面的诊断性能分析，对各参数进行受试者工作特征(ROC)曲线评价。
■与HFpEF和对照组相比，HFm+rEF患者的LVEDVi和LVESVi升高，LVEF降低。心肌劳损显示GLS显著降低，GCS,与其他组相比，HFm+rEF患者的GRS。HFpEF患者相对于对照组显示应变减少。在心脏磁共振成像（CMR）评估中，HFmrEF患者表现出升高的天然T1时间和ECV分数。天然T1在区分HFpEF与健康受试者方面特别有效。
■本机T1、ECV、和心肌应变参数在鉴定HFpEF方面具有重要的诊断价值。其中,相对于ECV，原生T1显示出较高的诊断效率，提供对早期HFpEF的关键见解。这些发现可以在完善心力衰竭患者的临床管理和治疗策略中发挥关键作用。
