Abstract：
Central centrifugal cicatricial alopecia (CCCA) is a scarring alopecia of multifactorial etiology that presents on the vertex as patchy areas of hair loss, spreading centrifugally over the scalp. It most commonly affects women of African descent, but cases among other ethnicities have also been reported. CCCA typically starts with thinning and breaking of the hair as the first sign of presentation, which eventually progresses to hair loss over the central part of the scalp, spreading symmetrically outwards to involve a larger area. Currently, there is no definitive cure for the disease; however, multiple management options are available, which should aim to be tailored to the individual patient. Owing to its cosmetic outcomes, the quality of life (QoL) of patients with central centrifugal cicatricial alopecia is also disturbed, as patients may face psychological and social stress due to their permanent hair loss. This article focuses on various aspects of the pathogenesis, clinical trials, quality of life, barriers faced by patients, and treatment of central centrifugal cicatricial alopecia.
摘要：
中央离心性瘢痕性脱发（CCCA）是多因素病因的瘢痕性脱发，在顶点上表现为脱发的斑片状区域，离心地散布在头皮上.它最常见的影响非洲裔妇女，但其他种族的病例也有报道。CCCA通常从头发变薄和断裂开始，作为演示的第一个标志，最终进展到头皮中央部分的脱发，对称地向外传播以涉及更大的区域。目前,这种疾病没有明确的治疗方法；然而，多个管理选项可用，这应该旨在为个体患者量身定做。由于其外观效果，中心性离心性瘢痕性脱发患者的生活质量（QoL）也受到干扰，因为患者可能会因为永久性脱发而面临心理和社会压力。本文重点介绍了发病机制的各个方面，临床试验,生活质量,患者面临的障碍，治疗中心性离心瘢痕性脱发。
