UNASSIGNED: This review provides current evidence regarding the potential benefits of TDM in IFI management. It discusses how TDM can enhance treatment response, safety, and address altered pharmacokinetics in specific patient populations.
UNASSIGNED: TDM plays a crucial role in achieving optimal therapeutic outcomes in IFI management, particularly for certain antifungal agents. Preclinical studies consistently show a link between therapeutic drug levels and antifungal efficacy. However, clinical research in mycology faces challenges due to patient heterogeneity and the diversity of fungal infections. TDM\'s potential advantages in guiding Echinocandin therapy for critically ill patients warrant further investigation. Additionally, for drugs like Posaconazole, assessing whether serum levels or alternative markers like saliva offer the best measure of efficacy is an intriguing question.
■本综述提供了有关TDM在国际金融机构管理中的潜在益处的最新证据。它讨论了TDM如何增强治疗反应,安全,并解决特定患者人群中药代动力学的改变。
■TDM在实现FI管理中的最佳治疗结果中起着至关重要的作用,特别是某些抗真菌剂。临床前研究一致显示治疗药物水平和抗真菌功效之间的联系。然而,由于患者异质性和真菌感染的多样性,真菌学临床研究面临挑战.TDM在指导棘球红素治疗危重患者方面的潜在优势值得进一步研究。此外,像泊沙康唑这样的药物,评估血清水平或唾液等替代标志物是否能提供最佳疗效指标是一个有趣的问题.