Abstract：
T-cell lymphoma is an extremely rare form of malignancy in the female genital tract. Most of the reported cases of lymphoma are B-cell lymphomas. A few cases of primary T-cell lymphomas involving the vagina or the vulva have been reported. We are reporting the first case of anaplastic large cell lymphoma (ALCL) presenting as a uterine cervical mass. The patient is a 24-year-old female who presented to the emergency room with a history of menorrhagia, night sweats and 40-pound weight loss. The diagnosis of ALCL was confirmed through immunohistochemical studies with strong CD30 and ALK expression. Fluorescent hybridization showed a rearrangement of the anaplastic lymphoma kinase (ALK) gene. Since ALCL may have a variable expression of T-cell antigens, the diagnosis may easily be missed when CD45 and/or CD3 is negative, and screening epithelial stains for carcinoma (e.g., p63 and EMA) are positive. CD30 must be performed to raise the consideration of ALCL when reniform nuclei are observed.
摘要：
T细胞淋巴瘤是女性生殖道中极为罕见的恶性肿瘤。大多数报道的淋巴瘤病例是B细胞淋巴瘤。已报道了几例涉及阴道或外阴的原发性T细胞淋巴瘤。我们正在报告首例表现为子宫颈肿块的间变性大细胞淋巴瘤（ALCL）。病人是一名24岁的女性，她出现在急诊室，有月经过多的病史，盗汗和40磅的减肥。通过具有强CD30和ALK表达的免疫组织化学研究证实了ALCL的诊断。荧光杂交显示间变性淋巴瘤激酶(ALK)基因重排。由于ALCL可能具有T细胞抗原的可变表达，当CD45和/或CD3为阴性时，很容易错过诊断，和筛查上皮染色的癌症(例如，p63和EMA)为阳性。当观察到肾形核时，必须进行CD30以提高对ALCL的考虑。
