Abstract：
UNASSIGNED: The relationship between primary hyperparathyroidism (PHPT) and bone sarcoma is debatable, especially after wider use of teriparatide treatment, concerns have intensified on the issue. Extensive search in English literature revealed 10 cases reported having PHPT and sarcomas. Besides, three cases of bone sarcoma occurring after teriparatide treatment had been reported. Hereby, we report a 51-year-old woman with a prolonged history of PHPT. She was diagnosed with chondrosarcoma 9 years after refusal and lack of treatment for PHPT. She was cured surgically for both chondrosarcoma and parathyroid adenoma at 1-year interval. So far, large cohorts did not show an increase in the incidence of bone sarcomas in PHPT. Several case observations, including the current one, as well as data from in vitro and rat studies, pointed out prolonged parathormone exposure, may be a risk for bone sarcomas. Under these circumstances, a safer attitude on individual basis would be the prevention of prolonged parathormone exposures.
摘要：
■原发性甲状旁腺功能亢进（PHPT）与骨肉瘤之间的关系尚有争议，特别是在广泛使用特立帕肽治疗后，对这个问题的担忧加剧了。在英语文献中进行了广泛的搜索，发现10例报告患有PHPT和肉瘤。此外,报道了3例特立帕肽治疗后发生的骨肉瘤。特此,我们报告了一名51岁的女性，有长期的PHPT病史。在拒绝和缺乏PHPT治疗9年后，她被诊断出患有软骨肉瘤。她以1年的间隔手术治愈了软骨肉瘤和甲状旁腺腺瘤。到目前为止,大型队列未显示PHPT中骨肉瘤的发生率增加.几个案例观察，包括现在的,以及体外和大鼠研究的数据，指出了长期暴露于甲状旁腺激素，可能是骨肉瘤的风险。在这种情况下,在个人基础上，更安全的态度是预防长期的副激素暴露。
