Abstract：
BACKGROUND: Food protein-induced allergic proctocolitis (FPIAP) is a nonimmunoglobulin (IgE)-mediated food hypersensitivity and the exact mechanisms that cause FPIAP are unknown. Chemokines play crucial roles in the development of allergic diseases.
OBJECTIVE: To examine serum levels of a group of chemokines in infants with FPIAP.
METHODS: In 67 infants with FPIAP and 65 healthy infants, we measured serum levels of mucosa-associated epithelial chemokine (MEC/CCL28), thymus-expressed chemokine (TECK/CCL25), CX3CL1 and macrophage inflammatory protein (MIP)-3a/CCL20.
RESULTS: Infants with FPIAP had a lower median value of MIP3a/CCL20 than healthy infants [0.7 (0-222) vs. 4 (0-249) pg/mL, respectively] (p < 0.001). Infants with MIP3a/CCL20 levels ≤0.95 pg/mL have 13.93 times more risk of developing FPIAP than infants with MIP3a/CCL20 levels >0.95 pg/mL. Serum MEC/CCL28, TECK/CCL25, and CX3CL1 levels were similar between the infants with FPIAP and the control group.
CONCLUSIONS: MIP3a/CCL20 serum levels were reduced in infants with FPIAP compared with healthy controls. Whether this finding has a role in pathogenesis remains to be determined.
OBJECTIVE: To examine serum levels of a group of chemokines in infants with FPIAP.
METHODS: In 67 infants with FPIAP and 65 healthy infants, we measured serum levels of mucosa-associated epithelial chemokine (MEC/CCL28), thymus-expressed chemokine (TECK/CCL25), CX3CL1 and macrophage inflammatory protein (MIP)-3a/CCL20.
RESULTS: Infants with FPIAP had a lower median value of MIP3a/CCL20 than healthy infants [0.7 (0-222) vs. 4 (0-249) pg/mL, respectively] (p < 0.001). Infants with MIP3a/CCL20 levels ≤0.95 pg/mL have 13.93 times more risk of developing FPIAP than infants with MIP3a/CCL20 levels >0.95 pg/mL. Serum MEC/CCL28, TECK/CCL25, and CX3CL1 levels were similar between the infants with FPIAP and the control group.
CONCLUSIONS: MIP3a/CCL20 serum levels were reduced in infants with FPIAP compared with healthy controls. Whether this finding has a role in pathogenesis remains to be determined.
摘要：
背景：食物蛋白诱导的过敏性直肠结肠炎（FPIAP）是一种非免疫球蛋白（IgE）介导的食物超敏反应，引起FPIAP的确切机制尚不清楚。趋化因子在过敏性疾病的发生发展中起着至关重要的作用。
目的：检测FPIAP患儿血清中一组趋化因子的水平。
方法：在67名FPIAP婴儿和65名健康婴儿中，我们测量了粘膜相关上皮趋化因子（MEC/CCL28）的血清水平，胸腺表达趋化因子（TECK/CCL25），CX3CL1和巨噬细胞炎性卵白(MIP)-3a/CCL20。
结果：FPIAP的婴儿MIP3a/CCL20的中位值低于健康婴儿[0.7（0-222）与4(0-249)pg/mL,分别](p<0.001)。MIP3a/CCL20水平≤0.95pg/mL的婴儿发生FPIAP的风险是MIP3a/CCL20水平>0.95pg/mL的婴儿的13.93倍。FPIAP患儿与对照组血清MEC/CCL28、TECK/CCL25和CX3CL1水平相似。
结论：与健康对照组相比，FPIAP患儿的MIP3a/CCL20血清水平降低。这一发现是否在发病机理中起作用尚待确定。
目的：检测FPIAP患儿血清中一组趋化因子的水平。
方法：在67名FPIAP婴儿和65名健康婴儿中，我们测量了粘膜相关上皮趋化因子（MEC/CCL28）的血清水平，胸腺表达趋化因子（TECK/CCL25），CX3CL1和巨噬细胞炎性卵白(MIP)-3a/CCL20。
结果：FPIAP的婴儿MIP3a/CCL20的中位值低于健康婴儿[0.7（0-222）与4(0-249)pg/mL,分别](p<0.001)。MIP3a/CCL20水平≤0.95pg/mL的婴儿发生FPIAP的风险是MIP3a/CCL20水平>0.95pg/mL的婴儿的13.93倍。FPIAP患儿与对照组血清MEC/CCL28、TECK/CCL25和CX3CL1水平相似。
结论：与健康对照组相比，FPIAP患儿的MIP3a/CCL20血清水平降低。这一发现是否在发病机理中起作用尚待确定。
