Abstract：
The aim for this pilot study was to investigate the effect of a sodium fluoride varnish on step height measured by a profilometer from human enamel worn by healthy volunteers with a novel in situ/ex vivo erosion design.
Healthy volunteers aged 18-70 years wore a palatal splint containing 8 human enamel samples and underwent two 3-day treatment periods for 6 h a day with a varnish containing sodium fluoride at 22,600 ppm and the control with the same ingredients but without fluoride. Each splint contained 4 polished and 4 unpolished samples. The interventions were applied to the surface of the enamel samples in randomised order, removed after 6 h, then immersed ex-vivo in 1 %, pH 2.7 citric acid for 2 min, repeated 4 times a day, over 2 days. Measurements of enamel were assessed blindly by microhardness on day 2 and by non-contact laser profilometry on day 3 for the two treatments.
24 volunteers, 2 males and 22 females aged 27-54 years, were screened and recruited. The delta microhardness, from polished samples removed at the end of day 2, for the control and fluoride treatment was 95.7 (22.9) kgf/mm2 and 123.7 (28.9) kgf/mm2, respectively (p < .005). The mean (SD) step height for the control polished enamel surfaces was 3.67 (2.07) µm and for the fluoride varnish was 1.79 (1.01) µm (p < .0005). The control unpolished enamel surfaces had a mean 2.09 (1.53) µm and the fluoride varnish was 2.11 (1.53) µm but no statistical difference was detected.
The results from this pilot study, utilizing an in-situ model where enamel was exposed to acid over the course of 2 days, demonstrated that a high fluoride varnish containing sodium fluoride at 22,600 ppm prevented erosive wear compared to a control on the polished enamel surfaces.
Intra-oral study demonstrated that a high fluoride varnish containing sodium fluoride at 22,600 ppm reduced erosive tooth wear.
Healthy volunteers aged 18-70 years wore a palatal splint containing 8 human enamel samples and underwent two 3-day treatment periods for 6 h a day with a varnish containing sodium fluoride at 22,600 ppm and the control with the same ingredients but without fluoride. Each splint contained 4 polished and 4 unpolished samples. The interventions were applied to the surface of the enamel samples in randomised order, removed after 6 h, then immersed ex-vivo in 1 %, pH 2.7 citric acid for 2 min, repeated 4 times a day, over 2 days. Measurements of enamel were assessed blindly by microhardness on day 2 and by non-contact laser profilometry on day 3 for the two treatments.
24 volunteers, 2 males and 22 females aged 27-54 years, were screened and recruited. The delta microhardness, from polished samples removed at the end of day 2, for the control and fluoride treatment was 95.7 (22.9) kgf/mm2 and 123.7 (28.9) kgf/mm2, respectively (p < .005). The mean (SD) step height for the control polished enamel surfaces was 3.67 (2.07) µm and for the fluoride varnish was 1.79 (1.01) µm (p < .0005). The control unpolished enamel surfaces had a mean 2.09 (1.53) µm and the fluoride varnish was 2.11 (1.53) µm but no statistical difference was detected.
The results from this pilot study, utilizing an in-situ model where enamel was exposed to acid over the course of 2 days, demonstrated that a high fluoride varnish containing sodium fluoride at 22,600 ppm prevented erosive wear compared to a control on the polished enamel surfaces.
Intra-oral study demonstrated that a high fluoride varnish containing sodium fluoride at 22,600 ppm reduced erosive tooth wear.
摘要：
目的：这项初步研究的目的是研究氟化钠清漆对台阶高度的影响，该台阶高度由具有新型原位/离体侵蚀设计的健康志愿者佩戴的人牙釉质的轮廓仪测量。
方法：年龄在18-70岁之间的健康志愿者佩戴了一个包含8个人类牙釉质样品的腭夹板，每天使用含有22,600ppm氟化钠的清漆进行为期3天的治疗，每天6小时，对照组使用相同成分但不含氟。每个夹板包含4个抛光样品和4个未抛光样品。干预措施以随机顺序应用于牙釉质样品的表面，6小时后移除，然后在1%的体外浸泡，pH2.7柠檬酸2分钟，一天重复4次,超过2天。对于两种处理，在第2天通过显微硬度和第3天通过非接触式激光轮廓测定法盲目评估牙釉质的测量。
结果：24名志愿者，2名男性和22名女性年龄27-54岁，被筛选和招募。δ显微硬度，对于对照和氟化物处理,在第2天结束时取出的抛光样品分别为95.7(22.9)kgf/mm2和123.7(28.9)kgf/mm2(p<0.005)。对照抛光搪瓷表面的平均(SD)台阶高度为3.67(2.07)μm,氟化物清漆为1.79(1.01)μm(p<.0005)。对照未抛光的搪瓷表面平均为2.09（1.53）µm，氟化物清漆为2.11（1.53）µm，但未检测到统计学差异。
结论：这项初步研究的结果，利用原位模型，其中搪瓷在2天的过程中暴露于酸，证明与抛光搪瓷表面的对照相比，含氟化钠含量为22,600ppm的高氟化物清漆可防止侵蚀磨损。
结论：口腔内研究表明，含氟化钠含量为22,600ppm的高氟化物清漆可减少侵蚀性牙齿磨损。
方法：年龄在18-70岁之间的健康志愿者佩戴了一个包含8个人类牙釉质样品的腭夹板，每天使用含有22,600ppm氟化钠的清漆进行为期3天的治疗，每天6小时，对照组使用相同成分但不含氟。每个夹板包含4个抛光样品和4个未抛光样品。干预措施以随机顺序应用于牙釉质样品的表面，6小时后移除，然后在1%的体外浸泡，pH2.7柠檬酸2分钟，一天重复4次,超过2天。对于两种处理，在第2天通过显微硬度和第3天通过非接触式激光轮廓测定法盲目评估牙釉质的测量。
结果：24名志愿者，2名男性和22名女性年龄27-54岁，被筛选和招募。δ显微硬度，对于对照和氟化物处理,在第2天结束时取出的抛光样品分别为95.7(22.9)kgf/mm2和123.7(28.9)kgf/mm2(p<0.005)。对照抛光搪瓷表面的平均(SD)台阶高度为3.67(2.07)μm,氟化物清漆为1.79(1.01)μm(p<.0005)。对照未抛光的搪瓷表面平均为2.09（1.53）µm，氟化物清漆为2.11（1.53）µm，但未检测到统计学差异。
结论：这项初步研究的结果，利用原位模型，其中搪瓷在2天的过程中暴露于酸，证明与抛光搪瓷表面的对照相比，含氟化钠含量为22,600ppm的高氟化物清漆可防止侵蚀磨损。
结论：口腔内研究表明，含氟化钠含量为22,600ppm的高氟化物清漆可减少侵蚀性牙齿磨损。
