PDF(Pubmed)
Abstract：
The purpose of this literature review was to determine if medications used to treat osteoporosis are also effective for treating osteoarthritis (OA).
A total of 40 relevant articles were identified. Studies were categorized into those (1) discussing estrogen and selective estrogen receptor modulators (SERMs), (2) bisphosphonates, (3) parathyroid hormone (PTH) analogs, and (4) denosumab, and (5) prior review articles. A large amount of evidence suggests that estrogen and SERMs are effective at reducing OA symptoms and disease progression. Evidence suggests that bisphosphonates, the most common medications used to treat osteoporosis, can reduce OA symptoms and disease progression. In vivo studies suggest that PTH analogs may improve the cartilage destruction associated with OA; however, few human trials have examined its use for OA. Denosumab is approved to treat osteoporosis, bone metastases, and certain types of breast cancer, but little study has been done with respect to its effect on OA. The current evidence indicates that medications used to treat osteoporosis are also effective for treating OA. Estrogen, SERMs, and bisphosphonates have the most potential as OA therapies. Less is known regarding the effectiveness of PTH analogs and denosumab in OA, and more research is needed.
A total of 40 relevant articles were identified. Studies were categorized into those (1) discussing estrogen and selective estrogen receptor modulators (SERMs), (2) bisphosphonates, (3) parathyroid hormone (PTH) analogs, and (4) denosumab, and (5) prior review articles. A large amount of evidence suggests that estrogen and SERMs are effective at reducing OA symptoms and disease progression. Evidence suggests that bisphosphonates, the most common medications used to treat osteoporosis, can reduce OA symptoms and disease progression. In vivo studies suggest that PTH analogs may improve the cartilage destruction associated with OA; however, few human trials have examined its use for OA. Denosumab is approved to treat osteoporosis, bone metastases, and certain types of breast cancer, but little study has been done with respect to its effect on OA. The current evidence indicates that medications used to treat osteoporosis are also effective for treating OA. Estrogen, SERMs, and bisphosphonates have the most potential as OA therapies. Less is known regarding the effectiveness of PTH analogs and denosumab in OA, and more research is needed.
摘要：
目的：这篇文献综述的目的是确定用于治疗骨质疏松症的药物是否也有效治疗骨关节炎（OA）。
结果：共确定了40篇相关文章。研究分为(1)讨论雌激素和选择性雌激素受体调节剂(SERMs)，(2)双膦酸盐，（3）甲状旁腺激素（PTH）类似物，和（4）denosumab，(5)事先审查的文章。大量证据表明，雌激素和SERM可有效减轻OA症状和疾病进展。证据表明双膦酸盐，最常见的治疗骨质疏松症的药物，可以减轻OA症状和疾病进展。体内研究表明，PTH类似物可以改善与OA相关的软骨破坏；然而，很少有人体试验检查其在OA中的用途。Denosumab被批准用于治疗骨质疏松症，骨转移,某些类型的乳腺癌，但是关于其对OA的影响的研究很少。目前的证据表明,用于治疗骨质疏松症的药物对于治疗OA也是有效的。雌激素,SERMs,和双膦酸盐作为OA疗法最有潜力。关于PTH类似物和denosumab在OA中的有效性知之甚少，需要更多的研究。
结果：共确定了40篇相关文章。研究分为(1)讨论雌激素和选择性雌激素受体调节剂(SERMs)，(2)双膦酸盐，（3）甲状旁腺激素（PTH）类似物，和（4）denosumab，(5)事先审查的文章。大量证据表明，雌激素和SERM可有效减轻OA症状和疾病进展。证据表明双膦酸盐，最常见的治疗骨质疏松症的药物，可以减轻OA症状和疾病进展。体内研究表明，PTH类似物可以改善与OA相关的软骨破坏；然而，很少有人体试验检查其在OA中的用途。Denosumab被批准用于治疗骨质疏松症，骨转移,某些类型的乳腺癌，但是关于其对OA的影响的研究很少。目前的证据表明,用于治疗骨质疏松症的药物对于治疗OA也是有效的。雌激素,SERMs,和双膦酸盐作为OA疗法最有潜力。关于PTH类似物和denosumab在OA中的有效性知之甚少，需要更多的研究。
